The Role of MicroRNAs in Cardiac Stem Cells

Stem cells are considered as the next generation drug treatment in patients with cardiovascular disease who are resistant to conventional treatment. Among several stem cells used in the clinical setting, cardiac stem cells (CSCs) which reside in the myocardium and epicardium of the heart have been s...

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Bibliographic Details
Published in:Stem Cells International 2015-01, Vol.2015 (2015), p.307-316-024
Main Authors: Purvis, Nima, Katare, Rajesh, Bahn, Andrew
Format: Article
Language:English
Subjects:
Antisense RNA
Cardiac patients
Cardiomyocytes
Cardiovascular disease
Cardiovascular diseases
Cell differentiation
Gene expression
Heart attacks
MicroRNA
Physiological aspects
Physiology
Proteins
Review
Smooth muscle
Stem cells
Studies
Transcription factors
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Summary:Stem cells are considered as the next generation drug treatment in patients with cardiovascular disease who are resistant to conventional treatment. Among several stem cells used in the clinical setting, cardiac stem cells (CSCs) which reside in the myocardium and epicardium of the heart have been shown to be an effective option for the source of stem cells. In normal circumstances, CSCs primarily function as a cell store to replace the physiologically depleted cardiovascular cells, while under the diseased condition they have been shown to experimentally regenerate the diseased myocardium. In spite of their major functional role, molecular mechanisms regulating the CSCs proliferation and differentiation are still unknown. MicroRNAs (miRs) are small, noncoding RNA molecules that regulate gene expression at the posttranscriptional level. Recent studies have demonstrated the important role of miRs in regulating stem cell proliferation and differentiation, as well as other physiological and pathological processes related to stem cell function. This review summarises the current understanding of the role of miRs in CSCs. A deeper understanding of the mechanisms by which miRs regulate CSCs may lead to advances in the mode of stem cell therapies for the treatment of cardiovascular diseases.
ISSN:1687-966X
1687-9678
1687-9678
DOI:10.1155/2015/194894