Brown Fat Expresses Adiponectin in Humans

The presence of brown adipose tissue (BAT) in humans is unclear. Pheochromocytomas (PHEO) are rare tumors of neuroectodermal origin which occur in 0.1-0.2% of patients with hypertension. We sought to evaluate the presence and activity of BAT surrounding adrenal PHEO in a well-studied sample of 11 pa...

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Bibliographic Details
Published in:International Journal of Endocrinology 2013-01, Vol.2013 (2013), p.65-70-008
Main Authors: Ciardi, Antonio, Giorgio, De Toma, Claudio, Letizia, Iacobellis, Gianluca, Marinelli, Cristiano, Zinnamosca, Laura, Serra, Valentina, Di Gioia, Cira, Petramala, Luigi, Chiappetta, Caterina
Format: Article
Language:English
Subjects:
Analysis
Blood pressure
Body fat
Brown adipose tissue
Clinical Study
Creatinine
Drug dosages
Endocrinology
Fasting
Glucose
Hypertension
Laboratories
Measurement
Patients
Protein hormones
Statistical analysis
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Summary:The presence of brown adipose tissue (BAT) in humans is unclear. Pheochromocytomas (PHEO) are rare tumors of neuroectodermal origin which occur in 0.1-0.2% of patients with hypertension. We sought to evaluate the presence and activity of BAT surrounding adrenal PHEO in a well-studied sample of 11 patients who were diagnosed with PHEO and then underwent adrenalectomy. Areas of white fat (WAT) and BAT surrounding PHEO were obtained by Laser Capture Microdissection for analysis of uncoupling protein (UCP)-1 and adiponectin mRNA expression. Adiponectin and UCP-1 mRNA levels were significantly higher in BAT than in WAT (0.62 versus 0.15 and 362.4 versus 22.1, resp., P
ISSN:1687-8337
1687-8345
DOI:10.1155/2013/126751