Oxidised phospholipids as biomarkers in human disease

Oxidised phospholipids (OxPLs) are generated from (poly)unsaturated diacyl- and alk(en)ylacyl glycerophospholipids under conditions of oxidative stress. OxPLs exert a wide variety of biological effects on diverse cell types in vitro and in vivo and are thought to play a role in the development of se...

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Bibliographic Details
Published in:Swiss medical weekly 2014, Vol.144 (5152), p.w14037-w14037
Main Authors: Philippova, Maria, Resink, Therese, Erne, Paul, Bochkov, Valery
Format: Article
Language:English
Subjects:
Animals
Apolipoprotein A-II - metabolism
Atherosclerosis - physiopathology
Biomarkers
Cardiovascular disease
Chronic Disease
Coronary Artery Disease - physiopathology
Coronary Restenosis - physiopathology
Diabetes Mellitus, Type 2 - physiopathology
Enzyme-Linked Immunosorbent Assay
Glycerophospholipids - metabolism
human pathologies
Humans
Lipoproteins, LDL - metabolism
Metabolic Syndrome - physiopathology
Nervous System Diseases - physiopathology
Oxidative Stress - physiology
Oxidized phospholipids
Renal Insufficiency - physiopathology
Spectrometry, Mass, Electrospray Ionization
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Summary:Oxidised phospholipids (OxPLs) are generated from (poly)unsaturated diacyl- and alk(en)ylacyl glycerophospholipids under conditions of oxidative stress. OxPLs exert a wide variety of biological effects on diverse cell types in vitro and in vivo and are thought to play a role in the development of several chronic diseases including atherosclerosis, a classical lipid-associated and inflammatory disorder. OxPLs are recognised as culprit molecular components responsible for the pathophysiological actions of oxidised low-density lipoproteins. There is growing interest in the potential use of OxPLs as biomarkers of human pathologies. Here we offer a brief overview of current detection methods and knowledge on relationships between levels of circulating OxPLs and disease progression, with particular emphasis on cardiovascular disease.
ISSN:1424-7860
1424-3997
DOI:10.4414/smw.2014.14037