Renal sympathetic denervation for treatment of resistant hypertension – Indigenous technique

Abstract Background The endovascular approach of ablation of renal sympathetic nerves is found to be effective in the treatment of uncontrolled hypertension. We report here our experience with the procedure in eight patients with drug resistant hypertension. Methods We included patients in whom the...

Full description

Saved in:
Bibliographic Details
Published in:Indian heart journal 2013-05, Vol.65 (3), p.239-242
Main Authors: Manakshe, Gajendra, Chakravarthi, R, Hussaini, Shaista, Menon, Rajeev, Srinivas Kumar, A, Ravi Kiran, V, Sundar, Gomathi, Narasimhan, C
Format: Article
Language:English
Subjects:
Adult
Cardiovascular
Catheter Ablation
Female
Humans
Hypertension - surgery
Kidney - innervation
Male
Middle Aged
Original
Radiofrequency ablation
Renal sympathetic denervation
Resistant hypertension
Sympathectomy - methods
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Background The endovascular approach of ablation of renal sympathetic nerves is found to be effective in the treatment of uncontrolled hypertension. We report here our experience with the procedure in eight patients with drug resistant hypertension. Methods We included patients in whom the blood pressure remained above 150/90 mmHg despite being on minimum three antihypertensive drugs. Radiofrequency ablation of the sympathetic nerves of both the renal arteries was done using conventional ablation catheters. The patients were followed at 1-month, 3 months and 6 months post procedure and blood pressure recorded. Results All patients underwent successful renal sympathetic denervation. The mean blood pressure of the patients was 181/102.5 mmHg before the procedure and the average requirement of antihypertensive drugs per day was 4. A significant reduction in both systolic and diastolic blood pressure was observed post procedure which sustained over the follow up period of six months. The mean blood pressure observed at 1-month, 3 and 6 months were 137.5/80 mmHg, 136/81 mmHg and 137.5/81 mmHg, respectively. The average requirement of the number of antihypertensives also was reduced to 2.5 at the end of 6 months. There were no procedural complications. Conclusion Catheter based renal denervation causes substantial and sustained blood pressure reduction without serious adverse events in patients with resistant hypertension.
ISSN:0019-4832
DOI:10.1016/j.ihj.2013.04.030