Modified EPOCH for high‐risk non‐Hodgkin lymphoma in sub‐Saharan Africa

Aggressive non‐Hodgkin lymphoma (NHL) is among the most common cancers in sub‐Saharan Africa (SSA), where CHOP is standard treatment and outcomes are poor. To address this, we treated 17 newly diagnosed adult patients in Malawi with Burkitt (n = 8), plasmablastic (n = 8), and primary effusion lympho...

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Bibliographic Details
Published in:Cancer medicine (Malden, MA) MA), 2020-01, Vol.9 (1), p.77-83
Main Authors: Zuze, Takondwa, Ellis, Grace K., Kasonkanji, Edwards, Kaimila, Bongani, Nyasosela, Richard, Nyirenda, Ruth, Tomoka, Tamiwe, Mulenga, Maurice, Chikasema, Maria, Tewete, Blessings, Mtangwanika, Asekanadziwa, Chiyoyola, Sarah, Chimzimu, Fred, Kampani, Coxcilly, Mhango, Wilberforce, Nicholas, Simon, Randall, Cara, Montgomery, Nathan D., Fedoriw, George, Westmoreland, Katherine D., Painschab, Matthew S., Gopal, Satish
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antineoplastic Combined Chemotherapy Protocols - administration & dosage
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Blood
Bone marrow
CD4 antigen
CD4 Lymphocyte Count
Cellular biology
Chemotherapy
Clinical Cancer Research
Cyclophosphamide - administration & dosage
Cyclophosphamide - adverse effects
Doxorubicin - administration & dosage
Doxorubicin - adverse effects
Drug therapy
Effusion
Enrollments
Etoposide - administration & dosage
Etoposide - adverse effects
Female
Follow-Up Studies
global health
HIV
HIV Infections - blood
HIV Infections - complications
HIV Infections - epidemiology
Human immunodeficiency virus
Humans
Laboratories
Lymphoma
Lymphoma, Non-Hodgkin - blood
Lymphoma, Non-Hodgkin - complications
Lymphoma, Non-Hodgkin - drug therapy
Lymphoma, Non-Hodgkin - mortality
Malawi - epidemiology
Male
Middle Aged
modified EPOCH
Neutropenia
Neutropenia - chemically induced
Neutropenia - epidemiology
Neutrophils
Non-Hodgkin's lymphoma
non‐Hodgkin lymphoma
Original Research
Prednisone - administration & dosage
Prednisone - adverse effects
Primary effusion lymphoma
Progression-Free Survival
Ribonucleic acid
RNA
RNA, Viral - blood
sub‐Saharan Africa
Ultrasonic imaging
Vincristine - administration & dosage
Vincristine - adverse effects
Young Adult
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Summary:Aggressive non‐Hodgkin lymphoma (NHL) is among the most common cancers in sub‐Saharan Africa (SSA), where CHOP is standard treatment and outcomes are poor. To address this, we treated 17 newly diagnosed adult patients in Malawi with Burkitt (n = 8), plasmablastic (n = 8), and primary effusion lymphoma (n = 1) with a modified EPOCH regimen between 2016 and 2019. Twelve patients (71%) were male and the median age was 40 years (range 16‐63). Eleven (65%) were HIV infected, median CD4 count was 218 cells/µL (range 9‐460), and nine (82%) had suppressed HIV RNA 
ISSN:2045-7634
2045-7634
DOI:10.1002/cam4.2631