Drug-Modified Contact Lenses-Properties, Release Kinetics, and Stability of Active Substances with Particular Emphasis on Cyclosporine A: A Review

The following review focuses on the manufacturing and parameterizing of ocular drug delivery systems (DDS) using polymeric materials to create soft contact lenses. It discusses the types of drugs embedded into contact lenses, the various polymeric materials used in their production, methods for asse...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2024-06, Vol.29 (11), p.2609
Main Authors: Rykowska, Iwona, Michałkiewicz, Ola, Nowak, Iwona, Nowak, Rafał
Format: Article
Language:English
Subjects:
Bioavailability
Biodegradation
Contact lenses
Contact Lenses, Hydrophilic
Cyclosporine - chemistry
Cyclosporine A stability
Drug Delivery Systems
Drug dosages
Drug Liberation
Drug Stability
Drugs
Eye diseases
Homeostasis
Humans
Kinetics
mechanic parameters
Mechanical properties
Molecular weight
Ophthalmic drugs
polymer matrix
Polymers
Polymers - chemistry
Review
therapeutic contact lenses
Vehicles
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Description
Summary:The following review focuses on the manufacturing and parameterizing of ocular drug delivery systems (DDS) using polymeric materials to create soft contact lenses. It discusses the types of drugs embedded into contact lenses, the various polymeric materials used in their production, methods for assessing the mechanical properties of polymers, and techniques for studying drug release kinetics. The article also explores strategies for investigating the stability of active substances released from contact lenses. It specifically emphasizes the production of soft contact lenses modified with Cyclosporine A (CyA) for the topical treatment of specific ocular conditions. The review pays attention to methods for monitoring the stability of Cyclosporine A within the discussed DDS, as well as investigating the influence of polymer matrix type on the stability and release of CyA.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules29112609