Chitosan-based films with cannabis oil as a base material for wound dressing application

This study focuses on obtaining and characterizing novel chitosan-based biomaterials containing cannabis oil to potentially promote wound healing. The primary active substance in cannabis oil is the non-psychoactive cannabidiol, which has many beneficial properties. In this study, three chitosan-bas...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2022-11, Vol.12 (1), p.18658-16, Article 18658
Main Authors: Chelminiak-Dudkiewicz, Dorota, Smolarkiewicz-Wyczachowski, Aleksander, Mylkie, Kinga, Wujak, Magdalena, Mlynarczyk, Dariusz T., Nowak, Pawel, Bocian, Szymon, Goslinski, Tomasz, Ziegler-Borowska, Marta
Format: Article
Language:English
Subjects:
639/638/298/54/990
639/638/455/953
Acute toxicity
Atomic force microscopy
Bandages - microbiology
Biocompatible Materials - pharmacology
Biomaterials
Biomedical materials
Cannabis
Cell culture
Chitosan
Humanities and Social Sciences
Humans
Marijuana
Microtox
multidisciplinary
Oil
Permeability
Science
Science (multidisciplinary)
Water vapor
Wound Healing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study focuses on obtaining and characterizing novel chitosan-based biomaterials containing cannabis oil to potentially promote wound healing. The primary active substance in cannabis oil is the non-psychoactive cannabidiol, which has many beneficial properties. In this study, three chitosan-based films containing different concentrations of cannabis oil were prepared. As the amount of oil increased, the obtained biomaterials became rougher as tested by atomic force microscopy. Such rough surfaces promote protein adsorption, confirmed by experiments assessing the interaction between human albumin with the obtained materials. Increased oil concentration also improved the films' mechanical parameters, swelling capacity, and hydrophilic properties, which were checked by the wetting angle measurement. On the other hand, higher oil content resulted in decreased water vapour permeability, which is essential in wound dressing. Furthermore, the prepared films were subjected to an acute toxicity test using a Microtox. Significantly, the film's increased cannabis oil content enhanced the antimicrobial effect against A. fischeri for films in direct contact with bacteria. More importantly, cell culture studies revealed that the obtained materials are biocompatible and, therefore, they might be potential candidates for application in wound dressing materials.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-23506-0