Comparative analysis of within-host diversity among vaccinated COVID-19 patients infected with different SARS-CoV-2 variants

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a rapidly evolving RNA virus that mutates within hosts and exists as viral quasispecies. Here, we evaluated the within-host diversity among vaccinated and unvaccinated individuals (n = 379) infected with different SARS-CoV-2 Variants of...

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Bibliographic Details
Published in:iScience 2022-11, Vol.25 (11), p.105438-105438, Article 105438
Main Authors: Al-Khatib, Hebah A., Smatti, Maria K., Ali, Fatma H., Zedan, Hadeel T., Thomas, Swapna, Ahmed, Muna N., El-kahlout, Reham A., Al Bader, Mashael A., Elgakhlab, Dina, Coyle, Peter V., Abu-Raddad, Laith J., Al Thani, Asma A., Yassine, Hadi M.
Format: Article
Language:English
Subjects:
Genomics
Immune response
Immunology
Virology
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Summary:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a rapidly evolving RNA virus that mutates within hosts and exists as viral quasispecies. Here, we evaluated the within-host diversity among vaccinated and unvaccinated individuals (n = 379) infected with different SARS-CoV-2 Variants of Concern. The majority of samples harbored less than 14 intra-host single-nucleotide variants (iSNVs). A deep analysis revealed a significantly higher intra-host diversity in Omicron samples than in other variants (p value 
ISSN:2589-0042
2589-0042
DOI:10.1016/j.isci.2022.105438