Lysophosphatidic Acid Signaling in Diabetic Nephropathy

Lysophosphatidic acid (LPA) is a bioactive phospholipid present in most tissues and body fluids. LPA acts through specific LPA receptors (LPAR1 to LPAR6) coupled with G protein. LPA binds to receptors and activates multiple cellular signaling pathways, subsequently exerting various biological functi...

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Bibliographic Details
Published in:International journal of molecular sciences 2019-06, Vol.20 (11), p.2850
Main Authors: Lee, Jong Han, Kim, Donghee, Oh, Yoon Sin, Jun, Hee-Sook
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Body fluids
Cancer
Cell growth
Cell proliferation
chronic kidney injury
Cytokines
Cytology
Diabetes
Diabetes mellitus
Diabetic Nephropathies - metabolism
Diabetic nephropathy
End-stage renal disease
Endoplasmic reticulum
Enzymes
Fibrosis
Glycerol
Humans
Hyperglycemia
Hypertension
Inflammation
Kidney diseases
Kinases
Lung cancer
Lung diseases
Lysophosphatidic acid
lysophosphatidic acid receptor
Lysophospholipids - metabolism
Nephropathy
Phospholipids
Physiology
Proteins
Reactive oxygen species
Renal Insufficiency, Chronic - metabolism
Review
Risk analysis
Risk factors
Signal transduction
Signal Transduction - physiology
Structure-function relationships
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Summary:Lysophosphatidic acid (LPA) is a bioactive phospholipid present in most tissues and body fluids. LPA acts through specific LPA receptors (LPAR1 to LPAR6) coupled with G protein. LPA binds to receptors and activates multiple cellular signaling pathways, subsequently exerting various biological functions, such as cell proliferation, migration, and apoptosis. LPA also induces cell damage through complex overlapping pathways, including the generation of reactive oxygen species, inflammatory cytokines, and fibrosis. Several reports indicate that the LPA-LPAR axis plays an important role in various diseases, including kidney disease, lung fibrosis, and cancer. Diabetic nephropathy (DN) is one of the most common diabetic complications and the main risk factor for chronic kidney diseases, which mostly progress to end-stage renal disease. There is also growing evidence indicating that the LPA-LPAR axis also plays an important role in inducing pathological alterations of cell structure and function in the kidneys. In this review, we will discuss key mediators or signaling pathways activated by LPA and summarize recent research findings associated with DN.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms20112850