Association between Pneumonia Development and Virulence Gene Expression in Carbapenem-Resistant Acinetobacter baumannii Isolated from Clinical Specimens

We investigated the virulence gene expression of carbapenem-resistant Acinetobacter baumanii (CRAB) isolated from the respiratory samples of patients with CRAB pneumonia and those with CRAB colonization to identify the virulence genes contributing to CRAB pneumonia’s development and mortality. Patie...

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Bibliographic Details
Published in:The Canadian journal of infectious diseases & medical microbiology 2023-12, Vol.2023, p.8265683-8
Main Authors: Bae, Ji Yun, Yun, Ina, Jun, Kang Il, Kim, Chung-Jong, Lee, Miae, Choi, Hee Jung
Format: Article
Language:English
Subjects:
Acinetobacter baumannii
Acinetobacter infections
Antibiotics
Bacterial pneumonia
Biofilms
Carbapenems
Causes of
Colonization
Complications and side effects
Criteria
Development and progression
Gene expression
Genes
Genetic aspects
Health aspects
Imipenem
Infections
Laboratories
Medical research
Medicine, Experimental
Mortality
Ostomy
Oxidative stress
Patients
Pneumonia
Polymerase chain reaction
Risk factors
Surgery
Tracheotomy
Ventilators
Virulence
Virulence (Microbiology)
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Summary:We investigated the virulence gene expression of carbapenem-resistant Acinetobacter baumanii (CRAB) isolated from the respiratory samples of patients with CRAB pneumonia and those with CRAB colonization to identify the virulence genes contributing to CRAB pneumonia’s development and mortality. Patients with CRAB identified from respiratory specimens were screened at a tertiary university hospital between January 2018 and January 2019. Patients were classified into CRAB pneumonia or CRAB colonization groups according to predefined clinical criteria. A. baumannii isolated from respiratory specimens was examined for the expression levels of ompA, uspA, hfq, hisF, feoA, and bfnL by quantitative reverse-transcription polymerase chain reaction. Among 156 patients with CRAB from respiratory specimens, 17 and 24 met the criteria for inclusion in the pneumonia and colonization groups, respectively. The expression level of ompA was significantly higher in the pneumonia group than in the colonization group (1.45 vs. 0.63, P=0.03). The expression levels of ompA (1.97 vs. 0.86, P=0.02), hisF (1.06 vs. 0.10, P
ISSN:1712-9532
1918-1493
DOI:10.1155/2023/8265683