The relationship between diabetic retinopathy and diabetic nephropathy in type 2 diabetes

• Published in: Frontiers in endocrinology (Lausanne) 2024, Vol.15, p.1292412-1292412
• Main Authors: Wang, Qian, Cheng, Haimei, Jiang, Shuangshuang, Zhang, Li, Liu, Xiaomin, Chen, Pu, Liu, Jiaona, Li, Ying, Liu, Xiaocui, Wang, Liqiang, Li, Zhaohui, Cai, Guangyan, Chen, Xiangmei, Dong, Zheyi
• Format: Article
• Language: English
• Subjects: diabetes mellitus; diabetic nephropathy; diabetic retinopathy; KW nodules; non-diabetic renal disease
• ISSN: 1664-2392; 1664-2392
• DOI: 10.3389/fendo.2024.1292412

Diabetic retinopathy (DR) and diabetic nephropathy (DN), are major microvascular complications of diabetes. DR is an important predictor of DN, but the relationship between the severity of DR and the pathological severity of diabetic glomerulopathy remains unclear. To investigate the relationship between severity of diabetic retinopathy (DR) and histological changes and clinical indicators of diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (T2DM). Patients with T2DM (n=272) who underwent a renal biopsy were eligible. Severity of DR was classified as non-diabetic retinopathy, non-proliferative retinopathy, and proliferative retinopathy (PDR). Relationship between DN and DR and the diagnostic efficacy of DR for DN were explored. DN had a higher prevalence of DR (86.4%) and DR was more severe. The sensitivity and specificity of DR in DN were 86.4% and 78.8%, while PDR was 26.4% and 98.5%, respectively. In DN patients, the severity of glomerular lesions (p=0.001) and prevalence of KW nodules (p