Prevalence of diabetic retinopathy and its relationship with glomerular filtration rate and other risk factors in patients with type 2 diabetes mellitus in Spain. DM2 HOPE study

•In Spain, diabetic retinopathy (DR) prevalence in type 2 diabetic patients was 14.9%.•DR was higher in women and older patients.•eGFR, duration of disease, HbA1c≥7% and high blood pressure were associated with DR.•DR was also higher in patients taking insulin.•Patients with DR used to have comorbid...

Full description

Saved in:
Bibliographic Details
Published in:Journal of clinical & translational endocrinology 2017-09, Vol.9, p.61-65
Main Authors: López, Maribel, Cos, Francesc Xavier, Álvarez-Guisasola, Fernando, Fuster, Eva
Format: Article
Language:English
Subjects:
Diabetes mellitus
Diabetic retinopathy
eGFR
Research Paper
Risk factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c521t-712695497e2663f3bb64f644ab571666476a0a1b412466c186db9efd3826cd7d3
cites cdi_FETCH-LOGICAL-c521t-712695497e2663f3bb64f644ab571666476a0a1b412466c186db9efd3826cd7d3
container_end_page 65
container_issue
container_start_page 61
container_title Journal of clinical & translational endocrinology
container_volume 9
creator López, Maribel
Cos, Francesc Xavier
Álvarez-Guisasola, Fernando
Fuster, Eva
description •In Spain, diabetic retinopathy (DR) prevalence in type 2 diabetic patients was 14.9%.•DR was higher in women and older patients.•eGFR, duration of disease, HbA1c≥7% and high blood pressure were associated with DR.•DR was also higher in patients taking insulin.•Patients with DR used to have comorbidities more frequently. Diabetic retinopathy (DR) is the leading cause of blindness in working age population in developed countries. Albuminuria and estimated glomerular filtration rate (eGFR) have been considered biomarkers for DR. This study aimed to investigate the prevalence of DR and its relationship with eGFR and other risk factors in type 2 diabetic patients (T2DM) in Spain. A cross-sectional and descriptive study has been performed in 14,266 patients. Clinical records were reviewed. Demographic data, clinical diagnoses, clinical variables, and results from laboratory tests were recorded. Prevalence rates of DR were calculated. Logistic regression analysis was applied to assess predictors of the DR presence/absence. DR prevalence was 14.9%, being more prevalent in women (p=0.0087) and in older patients (p
doi_str_mv 10.1016/j.jcte.2017.07.004
format article
fullrecord <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_65ae12f93e4f4de287c05580c0524402</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S2214623717300078</els_id><doaj_id>oai_doaj_org_article_65ae12f93e4f4de287c05580c0524402</doaj_id><sourcerecordid>1955607518</sourcerecordid><originalsourceid>FETCH-LOGICAL-c521t-712695497e2663f3bb64f644ab571666476a0a1b412466c186db9efd3826cd7d3</originalsourceid><addsrcrecordid>eNp9kl1rFDEUhgdRbKn9A15ILr3ZNcnkYwZEkFrbQqUF9TpkkjM7GWcnY5JZ2Z_lP2z2w9LeCCEn5LznOcnhLYq3BC8JJuJDv-xNgiXFRC5xXpi9KE4pJWwhaClfPjmfFOcx9hhjQjmXFXldnNAaC0klPS3-3gfY6AFGA8i3yDrdQHIGhbyPftKp2yI9WuRSzHeDTs6PsXMT-uNSh1aDX0OYBx1Q64YU9mmUA-yLfOogoODiL9Rqk3yIyI0oQx2MmbdHpO0EiB4bQ0RrGAaX5r3y-6TduERfvlF0fXd_iWKa7fZN8arVQ4TzYzwrfn69_HFxvbi9u7q5-Hy7MJyStJCEipqzWgIVomzLphGsFYzphksihGBSaKxJwwhlQhhSCdvU0NqyosJYacuz4ubAtV73agpurcNWee3U_sKHldIhj2oAJbgGQtu6BNYyC7SSBnNe4bxTxjDNrE8H1jQ3a7Amfz_o4Rn0eWZ0nVr5jeKCkxLjDHh_BAT_e4aY1NpFk0elR_BzVKTmXGDJSZWl9CA1wccYoH1sQ7DaWUf1amcdtbOOwnlhlovePX3gY8k_o2TBx4MA8sg3DoKKxu1cY10Ak_JM3P_4D1uJ13Q</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1955607518</pqid></control><display><type>article</type><title>Prevalence of diabetic retinopathy and its relationship with glomerular filtration rate and other risk factors in patients with type 2 diabetes mellitus in Spain. DM2 HOPE study</title><source>ScienceDirect Journals</source><source>PubMed Central</source><creator>López, Maribel ; Cos, Francesc Xavier ; Álvarez-Guisasola, Fernando ; Fuster, Eva</creator><creatorcontrib>López, Maribel ; Cos, Francesc Xavier ; Álvarez-Guisasola, Fernando ; Fuster, Eva</creatorcontrib><description><![CDATA[•In Spain, diabetic retinopathy (DR) prevalence in type 2 diabetic patients was 14.9%.•DR was higher in women and older patients.•eGFR, duration of disease, HbA1c≥7% and high blood pressure were associated with DR.•DR was also higher in patients taking insulin.•Patients with DR used to have comorbidities more frequently. Diabetic retinopathy (DR) is the leading cause of blindness in working age population in developed countries. Albuminuria and estimated glomerular filtration rate (eGFR) have been considered biomarkers for DR. This study aimed to investigate the prevalence of DR and its relationship with eGFR and other risk factors in type 2 diabetic patients (T2DM) in Spain. A cross-sectional and descriptive study has been performed in 14,266 patients. Clinical records were reviewed. Demographic data, clinical diagnoses, clinical variables, and results from laboratory tests were recorded. Prevalence rates of DR were calculated. Logistic regression analysis was applied to assess predictors of the DR presence/absence. DR prevalence was 14.9%, being more prevalent in women (p=0.0087) and in older patients (p<0.0001). Duration of disease (OR=5.3, IC95%=3.8–7.4; p<0.0001), eGFR<60ml/min/1.73m2 (OR=2.0, IC95% 1.6–2.4; p<0.0001), levels of HbA1c≥7% (OR=1.9, IC95%=1.5–2.3; p<0.0001) and high blood pressure (OR=1.6, IC95%=1.2–2.1; p=0.0032) were associated with higher risk of DR. DR was also more frequent in patients taking insulin (32,6% vs. 10,2%; p<0.0001). Around one in seven patients with T2DM has DR after nine years since diagnosis. Time since diagnosis, insulin therapy, cardiovascular profile, and renal dysfunction are associated with DR in patients with T2DM in Spain.]]></description><identifier>ISSN: 2214-6237</identifier><identifier>EISSN: 2214-6237</identifier><identifier>DOI: 10.1016/j.jcte.2017.07.004</identifier><identifier>PMID: 29067272</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Diabetes mellitus ; Diabetic retinopathy ; eGFR ; Research Paper ; Risk factors</subject><ispartof>Journal of clinical &amp; translational endocrinology, 2017-09, Vol.9, p.61-65</ispartof><rights>2017 The Authors</rights><rights>2017 The Authors 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c521t-712695497e2663f3bb64f644ab571666476a0a1b412466c186db9efd3826cd7d3</citedby><cites>FETCH-LOGICAL-c521t-712695497e2663f3bb64f644ab571666476a0a1b412466c186db9efd3826cd7d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651300/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S2214623717300078$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,3549,27924,27925,45780,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29067272$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>López, Maribel</creatorcontrib><creatorcontrib>Cos, Francesc Xavier</creatorcontrib><creatorcontrib>Álvarez-Guisasola, Fernando</creatorcontrib><creatorcontrib>Fuster, Eva</creatorcontrib><title>Prevalence of diabetic retinopathy and its relationship with glomerular filtration rate and other risk factors in patients with type 2 diabetes mellitus in Spain. DM2 HOPE study</title><title>Journal of clinical &amp; translational endocrinology</title><addtitle>J Clin Transl Endocrinol</addtitle><description><![CDATA[•In Spain, diabetic retinopathy (DR) prevalence in type 2 diabetic patients was 14.9%.•DR was higher in women and older patients.•eGFR, duration of disease, HbA1c≥7% and high blood pressure were associated with DR.•DR was also higher in patients taking insulin.•Patients with DR used to have comorbidities more frequently. Diabetic retinopathy (DR) is the leading cause of blindness in working age population in developed countries. Albuminuria and estimated glomerular filtration rate (eGFR) have been considered biomarkers for DR. This study aimed to investigate the prevalence of DR and its relationship with eGFR and other risk factors in type 2 diabetic patients (T2DM) in Spain. A cross-sectional and descriptive study has been performed in 14,266 patients. Clinical records were reviewed. Demographic data, clinical diagnoses, clinical variables, and results from laboratory tests were recorded. Prevalence rates of DR were calculated. Logistic regression analysis was applied to assess predictors of the DR presence/absence. DR prevalence was 14.9%, being more prevalent in women (p=0.0087) and in older patients (p<0.0001). Duration of disease (OR=5.3, IC95%=3.8–7.4; p<0.0001), eGFR<60ml/min/1.73m2 (OR=2.0, IC95% 1.6–2.4; p<0.0001), levels of HbA1c≥7% (OR=1.9, IC95%=1.5–2.3; p<0.0001) and high blood pressure (OR=1.6, IC95%=1.2–2.1; p=0.0032) were associated with higher risk of DR. DR was also more frequent in patients taking insulin (32,6% vs. 10,2%; p<0.0001). Around one in seven patients with T2DM has DR after nine years since diagnosis. Time since diagnosis, insulin therapy, cardiovascular profile, and renal dysfunction are associated with DR in patients with T2DM in Spain.]]></description><subject>Diabetes mellitus</subject><subject>Diabetic retinopathy</subject><subject>eGFR</subject><subject>Research Paper</subject><subject>Risk factors</subject><issn>2214-6237</issn><issn>2214-6237</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNp9kl1rFDEUhgdRbKn9A15ILr3ZNcnkYwZEkFrbQqUF9TpkkjM7GWcnY5JZ2Z_lP2z2w9LeCCEn5LznOcnhLYq3BC8JJuJDv-xNgiXFRC5xXpi9KE4pJWwhaClfPjmfFOcx9hhjQjmXFXldnNAaC0klPS3-3gfY6AFGA8i3yDrdQHIGhbyPftKp2yI9WuRSzHeDTs6PsXMT-uNSh1aDX0OYBx1Q64YU9mmUA-yLfOogoODiL9Rqk3yIyI0oQx2MmbdHpO0EiB4bQ0RrGAaX5r3y-6TduERfvlF0fXd_iWKa7fZN8arVQ4TzYzwrfn69_HFxvbi9u7q5-Hy7MJyStJCEipqzWgIVomzLphGsFYzphksihGBSaKxJwwhlQhhSCdvU0NqyosJYacuz4ubAtV73agpurcNWee3U_sKHldIhj2oAJbgGQtu6BNYyC7SSBnNe4bxTxjDNrE8H1jQ3a7Amfz_o4Rn0eWZ0nVr5jeKCkxLjDHh_BAT_e4aY1NpFk0elR_BzVKTmXGDJSZWl9CA1wccYoH1sQ7DaWUf1amcdtbOOwnlhlovePX3gY8k_o2TBx4MA8sg3DoKKxu1cY10Ak_JM3P_4D1uJ13Q</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>López, Maribel</creator><creator>Cos, Francesc Xavier</creator><creator>Álvarez-Guisasola, Fernando</creator><creator>Fuster, Eva</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20170901</creationdate><title>Prevalence of diabetic retinopathy and its relationship with glomerular filtration rate and other risk factors in patients with type 2 diabetes mellitus in Spain. DM2 HOPE study</title><author>López, Maribel ; Cos, Francesc Xavier ; Álvarez-Guisasola, Fernando ; Fuster, Eva</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c521t-712695497e2663f3bb64f644ab571666476a0a1b412466c186db9efd3826cd7d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Diabetes mellitus</topic><topic>Diabetic retinopathy</topic><topic>eGFR</topic><topic>Research Paper</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>López, Maribel</creatorcontrib><creatorcontrib>Cos, Francesc Xavier</creatorcontrib><creatorcontrib>Álvarez-Guisasola, Fernando</creatorcontrib><creatorcontrib>Fuster, Eva</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Journal of clinical &amp; translational endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>López, Maribel</au><au>Cos, Francesc Xavier</au><au>Álvarez-Guisasola, Fernando</au><au>Fuster, Eva</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence of diabetic retinopathy and its relationship with glomerular filtration rate and other risk factors in patients with type 2 diabetes mellitus in Spain. DM2 HOPE study</atitle><jtitle>Journal of clinical &amp; translational endocrinology</jtitle><addtitle>J Clin Transl Endocrinol</addtitle><date>2017-09-01</date><risdate>2017</risdate><volume>9</volume><spage>61</spage><epage>65</epage><pages>61-65</pages><issn>2214-6237</issn><eissn>2214-6237</eissn><abstract><![CDATA[•In Spain, diabetic retinopathy (DR) prevalence in type 2 diabetic patients was 14.9%.•DR was higher in women and older patients.•eGFR, duration of disease, HbA1c≥7% and high blood pressure were associated with DR.•DR was also higher in patients taking insulin.•Patients with DR used to have comorbidities more frequently. Diabetic retinopathy (DR) is the leading cause of blindness in working age population in developed countries. Albuminuria and estimated glomerular filtration rate (eGFR) have been considered biomarkers for DR. This study aimed to investigate the prevalence of DR and its relationship with eGFR and other risk factors in type 2 diabetic patients (T2DM) in Spain. A cross-sectional and descriptive study has been performed in 14,266 patients. Clinical records were reviewed. Demographic data, clinical diagnoses, clinical variables, and results from laboratory tests were recorded. Prevalence rates of DR were calculated. Logistic regression analysis was applied to assess predictors of the DR presence/absence. DR prevalence was 14.9%, being more prevalent in women (p=0.0087) and in older patients (p<0.0001). Duration of disease (OR=5.3, IC95%=3.8–7.4; p<0.0001), eGFR<60ml/min/1.73m2 (OR=2.0, IC95% 1.6–2.4; p<0.0001), levels of HbA1c≥7% (OR=1.9, IC95%=1.5–2.3; p<0.0001) and high blood pressure (OR=1.6, IC95%=1.2–2.1; p=0.0032) were associated with higher risk of DR. DR was also more frequent in patients taking insulin (32,6% vs. 10,2%; p<0.0001). Around one in seven patients with T2DM has DR after nine years since diagnosis. Time since diagnosis, insulin therapy, cardiovascular profile, and renal dysfunction are associated with DR in patients with T2DM in Spain.]]></abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>29067272</pmid><doi>10.1016/j.jcte.2017.07.004</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2214-6237
ispartof Journal of clinical & translational endocrinology, 2017-09, Vol.9, p.61-65
issn 2214-6237
2214-6237
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_65ae12f93e4f4de287c05580c0524402
source ScienceDirect Journals; PubMed Central
subjects Diabetes mellitus
Diabetic retinopathy
eGFR
Research Paper
Risk factors
title Prevalence of diabetic retinopathy and its relationship with glomerular filtration rate and other risk factors in patients with type 2 diabetes mellitus in Spain. DM2 HOPE study
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T03%3A03%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prevalence%20of%20diabetic%20retinopathy%20and%20its%20relationship%20with%20glomerular%20filtration%20rate%20and%20other%20risk%20factors%20in%20patients%20with%20type%202%20diabetes%20mellitus%20in%20Spain.%20DM2%20HOPE%20study&rft.jtitle=Journal%20of%20clinical%20&%20translational%20endocrinology&rft.au=L%C3%B3pez,%20Maribel&rft.date=2017-09-01&rft.volume=9&rft.spage=61&rft.epage=65&rft.pages=61-65&rft.issn=2214-6237&rft.eissn=2214-6237&rft_id=info:doi/10.1016/j.jcte.2017.07.004&rft_dat=%3Cproquest_doaj_%3E1955607518%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c521t-712695497e2663f3bb64f644ab571666476a0a1b412466c186db9efd3826cd7d3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1955607518&rft_id=info:pmid/29067272&rfr_iscdi=true