Plasmodium species mixed infections in two areas of Manhiça district, Mozambique

We compared the distribution patterns of individual Plasmodium species and mixed-species infections in two geographically close endemic areas, but showing environmental differences. Comparisons concerned circulating Plasmodium infections in both human and mosquito vector populations in the dry and w...

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Bibliographic Details
Published in:International journal of biological sciences 2005-01, Vol.1 (3), p.96-102
Main Authors: Marques, P X, Saúte, F, Pinto, V V, Cardoso, S, Pinto, J, Alonso, P L, Rosário, V E do, Arez, A P
Format: Article
Language:English
Subjects:
Adolescent
Animals
Child
Child, Preschool
Culicidae - parasitology
Humans
Infant
Malaria - epidemiology
Malaria - parasitology
mixed infections
Mozambique
Mozambique - epidemiology
Plasmodium
Plasmodium falciparum
Plasmodium falciparum - isolation & purification
Plasmodium malariae
Plasmodium ovale
Plasmodium ovale - isolation & purification
Polymerase Chain Reaction
Prevalence
Research Paper
Seasons
transmission
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Summary:We compared the distribution patterns of individual Plasmodium species and mixed-species infections in two geographically close endemic areas, but showing environmental differences. Comparisons concerned circulating Plasmodium infections in both human and mosquito vector populations in the dry and wet seasons, at a micro-epidemiological level (households). Both areas revealed a very high overall prevalence of infection, all year-round and in all age groups. Plasmodium falciparum was the predominant species, being found in the vast majority of infected individuals regardless of the presence of other species. Plasmodium malariae and Plasmodium ovale occurred almost exclusively in mixed infections. Seasonal variation in P. malariae prevalence was observed in one area but not in the other. A decrease in P. malariae prevalence concurred with a marked increase of P. falciparum prevalence. However this was strongly dependent on age and when analysing infections at the individual level, a different pattern between co-infecting species was unveiled. Regarding transmission patterns, in both areas, P. falciparum gametocytes predominated in single infections regardless of age and P. malariae gametocyte carriage increased when its overall prevalence decreased.
ISSN:1449-2288
1449-2288
DOI:10.7150/ijbs.1.96