Iron and leukemia: new insights for future treatments

Iron, an indispensable element for life, is involved in all kinds of important physiological activities. Iron promotes cell growth and proliferation, but it also causes oxidative stress damage. The body has a strict regulation mechanism of iron metabolism due to its potential toxicity. As a cancer o...

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Bibliographic Details
Published in:Journal of experimental & clinical cancer research 2019-09, Vol.38 (1), p.406-406, Article 406
Main Authors: Wang, Fang, Lv, Huanhuan, Zhao, Bin, Zhou, Liangfu, Wang, Shenghang, Luo, Jie, Liu, Junyu, Shang, Peng
Format: Article
Language:English
Subjects:
Animals
Care and treatment
Development and progression
Disease Management
Disease Susceptibility
Drug Carriers
Drug Delivery Systems
Ferroptosis
Humans
Iron
Iron - chemistry
Iron - metabolism
Iron in the body
Iron-based nanoparticles
Leukemia
Leukemia - etiology
Leukemia - metabolism
Leukemia - therapy
Metabolic Networks and Pathways - drug effects
Metabolism
Metal Nanoparticles - chemistry
Molecular Targeted Therapy
Oxidation-Reduction - drug effects
Oxidative Stress
Reactive oxygen species
Review
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Summary:Iron, an indispensable element for life, is involved in all kinds of important physiological activities. Iron promotes cell growth and proliferation, but it also causes oxidative stress damage. The body has a strict regulation mechanism of iron metabolism due to its potential toxicity. As a cancer of the bone marrow and blood cells, leukemia threatens human health seriously. Current studies suggest that dysregulation of iron metabolism and subsequent accumulation of excess iron are closely associated with the occurrence and progress of leukemia. Specifically, excess iron promotes the development of leukemia due to the pro-oxidative nature of iron and its damaging effects on DNA. On the other hand, leukemia cells acquire large amounts of iron to maintain rapid growth and proliferation. Therefore, targeting iron metabolism may provide new insights for approaches to the treatment of leukemia. This review summarizes physiologic iron metabolism, alternations of iron metabolism in leukemia and therapeutic opportunities of targeting the altered iron metabolism in leukemia, with a focus on acute leukemia.
ISSN:1756-9966
0392-9078
1756-9966
DOI:10.1186/s13046-019-1397-3