Longitudinal associations of physical activity with plasma metabolites among colorectal cancer survivors up to 2 years after treatment

We investigated longitudinal associations of moderate-to-vigorous physical activity (MVPA) and light-intensity physical activity (LPA) with plasma concentrations of 138 metabolites after colorectal cancer (CRC) treatment. Self-reported physical activity data and blood samples were obtained at 6 week...

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Bibliographic Details
Published in:Scientific reports 2021-07, Vol.11 (1), p.13738-13738, Article 13738
Main Authors: van Roekel, Eline H., Bours, Martijn J. L., van Delden, Linda, Breukink, Stéphanie O., Aquarius, Michèl, Keulen, Eric T. P., Gicquiau, Audrey, Viallon, Vivian, Rinaldi, Sabina, Vineis, Paolo, Arts, Ilja C. W., Gunter, Marc J., Leitzmann, Michael F., Scalbert, Augustin, Weijenberg, Matty P.
Format: Article
Language:English
Subjects:
631/45/320
692/308/174
692/499
692/699/67/1504
692/699/67/2324
Aged
Amino acids
Arginine - blood
Cancer Survivors
Carnitine - analogs & derivatives
Carnitine - blood
Citrulline
Citrulline - blood
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - blood
Colorectal Neoplasms - drug therapy
Colorectal Neoplasms - genetics
Colorectal Neoplasms - pathology
Exercise
Exercise - physiology
Female
Histidine
Histidine - blood
Humanities and Social Sciences
Humans
Inflammation
Lipid metabolism
Lipids
Longitudinal Studies
Lysophosphatidylcholines - blood
Male
Mass spectrometry
Mass spectroscopy
Metabolites
Metabolome - genetics
Middle Aged
multidisciplinary
Physical activity
Quality of Life
Science
Science (multidisciplinary)
Self Report
Sphingomyelins - blood
Tandem Mass Spectrometry
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Summary:We investigated longitudinal associations of moderate-to-vigorous physical activity (MVPA) and light-intensity physical activity (LPA) with plasma concentrations of 138 metabolites after colorectal cancer (CRC) treatment. Self-reported physical activity data and blood samples were obtained at 6 weeks, and 6, 12 and 24 months post-treatment in stage I-III CRC survivors (n = 252). Metabolite concentrations were measured by tandem mass spectrometry (BIOCRATES Absolute IDQ p180 kit). Linear mixed models were used to evaluate confounder-adjusted longitudinal associations. Inter-individual (between-participant differences) and intra-individual associations (within-participant changes over time) were assessed as percentage difference in metabolite concentration per 5 h/week of MVPA or LPA. At 6 weeks post-treatment, participants reported a median of 6.5 h/week of MVPA (interquartile range:2.3,13.5) and 7.5 h/week of LPA (2.0,15.8). Inter-individual associations were observed with more MVPA being related (FDR-adjusted q-value 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-92279-9