The Neurovascular Unit in Dementia: An Opinion on Current Research and Future Directions

[...]the lack of efficacy for amyloid-based targets may suggest amyloid is a by-product rather than causative agent of the disease process. [...]the potential efficacy in a sub-group of early AD (Tolar et al., 2020) suggests that amyloid is a late occurrence in the disease process, at which stage ir...

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Bibliographic Details
Published in:Frontiers in aging neuroscience 2021-07, Vol.13, p.721937-721937
Main Authors: Beishon, Lucy, Panerai, Ronney B.
Format: Article
Language:English
Subjects:
Alzheimer's disease
Antihypertensives
Biomarkers
Blood-brain barrier
Brain research
cerebrovascular disease
Cognitive ability
cognitive dysfunction
Dementia
Dementia disorders
Health care
Health risk assessment
Hemodynamics
Hypotheses
Investigations
Longitudinal studies
Medical imaging
Metabolites
mild cognitive impairment
Neuroscience
neurovascular coupling
Older people
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Summary:[...]the lack of efficacy for amyloid-based targets may suggest amyloid is a by-product rather than causative agent of the disease process. [...]the potential efficacy in a sub-group of early AD (Tolar et al., 2020) suggests that amyloid is a late occurrence in the disease process, at which stage irrevocable damage and cognitive decline has ensued. [...]amyloid deposition damages the cerebrovasculature, both structurally and functionally, therefore worsening hypoperfusion in a cyclical fashion (Nelson et al., 2016). [...]deficiencies occurring in one or more components of the NVU threaten this tightly coordinated system.
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2021.721937