Loading…

Potential and safety tests of egg drop syndrome candidate vaccine from Medan isolate, Indonesia

The study was aimed to prepare and examine the potential and safety concerns of egg drop syndrome (EDS) vaccine candidate seed. The potential and safety trials of EDS Medan isolate vaccine need to be done before commercial scale of EDS vaccines are made. The safety test of EDS candidate vaccine was...

Full description

Saved in:
Bibliographic Details
Published in:Veterinary World 2018-11, Vol.11 (11), p.1637-1640
Main Authors: Kencana, Gusti Ayu Yuniati, Suartha, Nyoman, Kardena, I Made, Dewi, Gusti Ayu Mayani Kristina, Nurhandayani, Arini, Syamsidar, Agustina, Kadek Karang
Format: Article
Language:English
Subjects:
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The study was aimed to prepare and examine the potential and safety concerns of egg drop syndrome (EDS) vaccine candidate seed. The potential and safety trials of EDS Medan isolate vaccine need to be done before commercial scale of EDS vaccines are made. The safety test of EDS candidate vaccine was tested on 4-week-old specified pathogen-free chickens in an experimentally isolated enclosure. The result of the safety test obtained 2 hemagglutination inhibition (HI) unit of geometric mean titer antibody post-vaccination. However, the potency test of the EDS candidate vaccine was conducted on 17-week-old laying hens. Test results of the EDS potency vaccine in layer obtained antibody titer increased in every week of blood taking with average titer of antibody: Before vaccinated was 2 HI unit, 1 week after vaccination was 2 HI unit, 2 weeks post-vaccination was 2 HI unit, and 3 weeks after vaccination was 2 HI units. In contrast, decreasing trend was observed in control group (unvaccinated chicken). Serologically, the seed vaccine of EDS virus isolates from Medan was able to produce protective antibody titers starting in the 2 and 3 weeks post-vaccination.
ISSN:0972-8988
2231-0916
DOI:10.14202/vetworld.2018.1637-1640