Does appendectomy increase the risk of colorectal adenocarcinoma?

Colorectal cancer ranks third as the most common malignancy in the United States and represents the second leading cause of cancer-related mortality. The appendix is thought to have a productive effect against colorectal carcinoma by the immune function based on its association with substantial lymp...

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Bibliographic Details
Published in:Central European journal of medicine 2009-09, Vol.4 (3), p.315-319
Main Authors: Ergul, Emre, Gozetlik, Erdal Ozgur
Format: Article
Language:English
Subjects:
Adenocarcinoma
Appendectomy
Biomedicine
Colorectal carcinoma
Internal Medicine
Maternal and Child Health
Medicine
Medicine & Public Health
Rectum
Reproductive Medicine
Research Article
Surgery
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Summary:Colorectal cancer ranks third as the most common malignancy in the United States and represents the second leading cause of cancer-related mortality. The appendix is thought to have a productive effect against colorectal carcinoma by the immune function based on its association with substantial lymphatic tissue. But, an appendectomy is still the most commonly performed emergency surgical procedure. It is aimed to assess the association between colorectal cancer and appendicectomy. The medical records of 455 patients who received medical and/or surgical treatment with the diagnosis of colorectal carcinoma in two medical centers in a-five-year period were reviewed. The patients were divided into subgroups according to the colonic localization of the tumor, appendectomy status and their body mass indexes (BMI). In order to define independent predictors of colon adeno-cancer, multiple logistic regression analysis was used. Statistically significant variables according to the univariate statistics were selected as candidate variables for multiple logistic regression analysis. A p-value
ISSN:1895-1058
2391-5463
1644-3640
2391-5463
DOI:10.2478/s11536-009-0045-2