MicroRNA-21 Contributes to Acute Liver Injury in LPS-Induced Sepsis Mice by Inhibiting PPARα Expression

The severity of sepsis may be associated with excessive inflammation, thus leading to acute liver injury. MicroRNA-21 is highly expressed in the liver of a variety of inflammation-related diseases, and PPARα is also proved to participate in regulating inflammation. In the present study, the LPS-indu...

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Bibliographic Details
Published in:PPAR research 2020, Vol.2020 (2020), p.1-7
Main Authors: Wang, Lu, Zhou, Jianlin, Tian, Dan, Wu, Miao, Du, Xianjin, Zhan, Liying
Format: Article
Language:English
Subjects:
Binding sites
Cytokines
Gene expression
Infection
Inflammation
Laboratory animals
Lipopolysaccharides
Liver
MicroRNA
MicroRNAs
miRNA
Pathogenesis
Proteins
Sepsis
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Summary:The severity of sepsis may be associated with excessive inflammation, thus leading to acute liver injury. MicroRNA-21 is highly expressed in the liver of a variety of inflammation-related diseases, and PPARα is also proved to participate in regulating inflammation. In the present study, the LPS-induced sepsis model was established. We found that microRNA-21 expression was upregulated in the liver of sepsis mice, and microRNA-21 inhibition significantly reduced the liver injury. The expression of liver injury markers, inflammation cytokines, and PPARα in the septic mice was higher than in antagomir-21 treated septic mice. In addition, we also found that PPARα is the target gene of microRNA-21; PPARα antagonist GW6471 could reverse the effect of antagomir-21. In conclusion, our study illustrated that microRNA-21 exacerbate acute liver injury in sepsis mice by inhibiting PPARα expression.
ISSN:1687-4757
1687-4765
DOI:10.1155/2020/6633022