Association mapping of genetic risk factors for chronic wasting disease in wild deer

Chronic wasting disease (CWD) is a fatal transmissible spongiform encephalopathy affecting North American cervids. We assessed the feasibility of association mapping CWD genetic risk factors in wild white‐tailed deer (Odocoileus virginianus) and mule deer (Odocoileus hemionus) using a panel of bovin...

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Bibliographic Details
Published in:Evolutionary applications 2013-02, Vol.6 (2), p.340-352
Main Authors: Matsumoto, Tomomi, Samuel, Michael D., Bollinger, Trent, Pybus, Margo, Coltman, David W.
Format: Article
Language:English
Subjects:
Alzheimer's disease
Animal populations
Cervidae
Chronic wasting disease
Deer
Gene mapping
Genetic engineering
Genetic markers
genetic risk factor
Genomes
Laboratories
Linkage disequilibrium
microsatellite markers
Microsatellites
mule deer
Mutation
Neurofibromin 1
NF1
Odocoileus
Original
Prion protein
PRNP
Risk factors
Sheep
Studies
Transmissible spongiform encephalopathy
white‐tailed deer
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Summary:Chronic wasting disease (CWD) is a fatal transmissible spongiform encephalopathy affecting North American cervids. We assessed the feasibility of association mapping CWD genetic risk factors in wild white‐tailed deer (Odocoileus virginianus) and mule deer (Odocoileus hemionus) using a panel of bovine microsatellite markers from three homologous deer linkage groups predicted to contain candidate genes. These markers had a low cross‐species amplification rate (27.9%) and showed weak linkage disequilibrium (
ISSN:1752-4571
1752-4571
DOI:10.1111/eva.12003