Does Platelet-Rich Fibrin Decrease Dimensional Changes and Improve Postoperative Comfort in Post-Extraction Sockets? An Overview of Systematic Reviews

This overview aimed to evaluate the methods, quality, and outcomes of systematic reviews (SRs) conducted to investigate the effects of platelet-rich fibrin (PRF) in dental sockets on promoting bone regeneration and soft tissue healing and diminishing the incidence of pain, swelling, trismus, and alv...

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Bibliographic Details
Published in:Applied sciences 2020-09, Vol.10 (17), p.5750
Main Authors: Moraschini, Vittorio, Mourão, Carlos Fernando de Almeida Barros, Machado, Rafael Coutinho de Mello, Nascimento, Jhonathan Raphaell Barros, Javid, Kayvon, Calasans-Maia, Monica Diuana, Cardarelli, Angelo, Montemezzi, Pietro, Calasans-Maia, Jose de Albuquerque
Format: Article
Language:English
Subjects:
alveolar socket preservation
Biomedical materials
Bone growth
Bone healing
Bones
Clinical trials
Cytokines
Dentistry
Fibrin
Grey literature
Growth factors
Healing
Meta-analysis
Osteitis
Pain
Periodontics
platelet-rich fibrin
PRF
Quality assessment
Quality control
Regeneration
Regeneration (physiology)
Reviews
Soft tissues
Software
Stem cells
Surgery
Teeth
tooth extraction
Transplants & implants
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Summary:This overview aimed to evaluate the methods, quality, and outcomes of systematic reviews (SRs) conducted to investigate the effects of platelet-rich fibrin (PRF) in dental sockets on promoting bone regeneration and soft tissue healing and diminishing the incidence of pain, swelling, trismus, and alveolar osteitis after tooth extraction. An electronic search without date or language restriction was done in PubMed/MEDLINE, Cochrane, and Web of Science until March 2020. Eligibility criteria included SRs that assessed the effect of PRF for human alveolar socket preservation. The quality assessment of the included studies was performed using AMSTAR 2 guidelines. The protocol of this overview was recorded in PROSPERO under the number CRD42018089617. The search and selection process yielded 13 studies published between 2011 and 2018. The analysis of the studies showed inconclusive data for the effect of the PRF and the dimensional changes. There is no definitive evidence for the impact of using PRF alone on bone regeneration in post-extraction sockets. The use of PRF improves soft tissue healing and reduces pain, bleeding, and osteitis in post-extraction sockets.
ISSN:2076-3417
2076-3417
DOI:10.3390/app10175750