Bioactivities of Lyngbyabellins from Cyanobacteria of Moorea and Okeania Genera

Cyanobacteria are reported as rich sources of secondary metabolites that provide biological activities such as enzyme inhibition and cytotoxicity. Ten depsipeptide derivatives (lyngbyabellins) were isolated from a Malaysian and a Red Sea sp.: lyngbyabellins G ( ), O ( ), P ( ), H ( ), A ( ), 27-deox...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2020-09, Vol.25 (17), p.3986
Main Authors: Fathoni, Imam, Petitbois, Julie G, Alarif, Walied M, Abdel-Lateff, Ahmed, Al-Lihaibi, Sultan S, Yoshimura, Erina, Nogata, Yasuyuki, Vairappan, Charles S, Sholikhah, Eti Nurwening, Okino, Tatsufumi
Format: Article
Language:English
Subjects:
antifouling
Antifouling substances
Antimalarial agents
Antimalarials - pharmacology
antiplasmodial
Antiprotozoal agents
Biocompatibility
Biofouling
Breast cancer
Cell Death - drug effects
Chains
Chromatography
Cyanobacteria
Cyanobacteria - chemistry
cytotoxic
Cytotoxic agents
Cytotoxicity
Depsipeptides - chemistry
Depsipeptides - isolation & purification
Depsipeptides - pharmacology
Humans
Larvae
Malaria
MCF-7 Cells
Metabolites
Moorea
Okeania
Parasites
Secondary metabolites
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Summary:Cyanobacteria are reported as rich sources of secondary metabolites that provide biological activities such as enzyme inhibition and cytotoxicity. Ten depsipeptide derivatives (lyngbyabellins) were isolated from a Malaysian and a Red Sea sp.: lyngbyabellins G ( ), O ( ), P ( ), H ( ), A ( ), 27-deoxylyngbyabellin A ( ), and homohydroxydolabellin ( ). This study indicated that lyngbyabellins displayed cytotoxicity, antimalarial, and antifouling activities. The isolated compounds were tested for cytotoxic effect against human breast cancer cells (MCF7), for antifouling activity against barnacle larvae, and for antiplasmodial effect towards . Lyngbyabellins A and G displayed potent antiplasmodial effect against , whereas homohydroxydolabellin showed moderate effect. For antifouling activity, the side chain decreases the activity slightly, but the essential feature is the acyclic structure. As previously reported, the acyclic lyngbyabellins are less cytotoxic than the corresponding cyclic ones, and the side chain increases cytotoxicity. This study revealed that lyngbyabellins, despite being cytotoxic agents as previously reported, also exhibit antimalarial and antifouling activities. The unique chemical structures and functionalities of lyngbyabellin play an essential role in their biological activities.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules25173986