Evaluation of neutralizing antibody titers against SARS-CoV-2 JN.1 omicron subvariant during pregnancy - A case series study

SARS-CoV-2 infection during pregnancy poses health risks to both mother and fetus. This study investigates neutralizing antibodies (NAbs) against the SARS-CoV-2 JN.1 Omicron subvariant in pregnant women, focusing on responses to natural infection, vaccination, and passive immunity. A single-center,...

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Bibliographic Details
Published in:Heliyon 2025-01, Vol.11 (1), p.e41249, Article e41249
Main Authors: Didembourg, Marie, David, Clara, Morimont, Laure, Cransquint, Eva, Favresse, Julien, Douxfils, Jonathan, Gillot, Constant
Format: Article
Language:English
Subjects:
Maternal immunity
Neutralizing antibodies
Passive immunity
Pregnancy
SARS-CoV-2
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Summary:SARS-CoV-2 infection during pregnancy poses health risks to both mother and fetus. This study investigates neutralizing antibodies (NAbs) against the SARS-CoV-2 JN.1 Omicron subvariant in pregnant women, focusing on responses to natural infection, vaccination, and passive immunity. A single-center, prospective study collected blood samples from 19 pregnant women at various pregnancy stages and postpartum. NAb titers were analyzed using a pseudovirus neutralization assay, with statistical analyses (p-value
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2024.e41249