Anti-Acne Vulgaris Potential of the Ethanolic Extract of Mesua ferrea L. Flowers

Acne vulgaris is a common chronic inflammatory skin disease. In the present study, we reported the anti-acne vulgaris effect of the Mesua ferrea (M. ferrea) flower extract. The extract was evaluated for three anti-acne-causing bacteria properties including Cutibacterium acnes (C. acnes), Staphylococ...

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Published in:Cosmetics (Basel) 2021-12, Vol.8 (4), p.107
Main Authors: Nakyai, Wongnapa, Pabuprapap, Wachirachai, Sroimee, Wichuda, Ajavakom, Vachiraporn, Yingyongnarongkul, Boon-ek, Suksamrarn, Apichart
Format: Article
Language:English
Subjects:
Acids
Acne
anti-acne
anti-bacteria
anti-inflammation
Anti-inflammatory agents
anti-oxidant
anti-tyrosinase
Antioxidants
Bacteria
Cutibacterium acnes
Ethanol
Flowers
Flowers & plants
Free radicals
Gene expression
Gram-positive bacteria
Lipopolysaccharides
Macrophages
Mesua ferrea
Minimum inhibitory concentration
Natural products
Nitric oxide
Plant extracts
Skin diseases
Staphylococcus aureus
Staphylococcus epidermidis
Tumor necrosis factor-TNF
Tumor necrosis factor-α
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description Acne vulgaris is a common chronic inflammatory skin disease. In the present study, we reported the anti-acne vulgaris effect of the Mesua ferrea (M. ferrea) flower extract. The extract was evaluated for three anti-acne-causing bacteria properties including Cutibacterium acnes (C. acnes), Staphylococcus epidermidis (S. epidermidis) and Staphylococcus aureus (S. aureus). The results indicated that the M. ferrea flower extract could be considered as the bactericidal agent against S. epidermidis and S. aureus with MIC values of 0.78 and 6.25 mg mL−1 and MBC values of 1.56 and 12.50 mg mL−1 and the bacteriostatic agent against C. acnes with MIC and MBC values of 3.12 and 25.00 mg mL−1, respectively. The extract at a concentration of 25 µg mL−1 also presented potent anti-inflammatory activity with a significant decrease of nitric oxide (NO) and tumor necrosis factor (TNF)-α productions in RAW 264.7 macrophage cells stimulated by LPS. In addition, the extract showed moderate to weak anti-oxidative capacities against DPPH, ABTS, FRAP and NO assays and also showed weak anti-tyrosinase activity. M. ferrea flower extract may serve as the alternative natural anti-acne formulations.
doi_str_mv 10.3390/cosmetics8040107
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ispartof Cosmetics (Basel), 2021-12, Vol.8 (4), p.107
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subjects Acids
Acne
anti-acne
anti-bacteria
anti-inflammation
Anti-inflammatory agents
anti-oxidant
anti-tyrosinase
Antioxidants
Bacteria
Cutibacterium acnes
Ethanol
Flowers
Flowers & plants
Free radicals
Gene expression
Gram-positive bacteria
Lipopolysaccharides
Macrophages
Mesua ferrea
Minimum inhibitory concentration
Natural products
Nitric oxide
Plant extracts
Skin diseases
Staphylococcus aureus
Staphylococcus epidermidis
Tumor necrosis factor-TNF
Tumor necrosis factor-α
title Anti-Acne Vulgaris Potential of the Ethanolic Extract of Mesua ferrea L. Flowers
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