Measurement properties of the EQ-5D-5L in sub-health: evidence based on primary health care workers in China

• Published in: Health and quality of life outcomes 2023-03, Vol.21 (1), p.22-22, Article 22
• Main Authors: Liu, Yueyue, Wan, Chuchuan, Xi, Xiaoyu
• Format: Article
• Language: English
• Subjects: China; Chinese medicine; Chronic illnesses; Correlation coefficient; Correlation coefficients; Cronbach's alpha; Cross-Sectional Studies; Disease; EQ-5D-5L; Global health; Health care; Health-related quality of life; Humans; Investigations; Measurement properties; Medical personnel; Missing data; Physiology; Primary care; Primary Health Care; Psychometrics; Public health; Quality of Life; Questionnaires; Reproducibility of Results; Sub-health; Subgroups; Surveys and Questionnaires; Validity
• ISSN: 1477-7525; 1477-7525
• DOI: 10.1186/s12955-023-02105-1

Sub-health which is the state between health and disease is a major global public health challenge. As a reversible stage, sub-health can work as a effective tool for the early detection or prevention of chronic disease. The EQ-5D-5L (5L) is a widely used, generic preference-based instrument while its validity in measuring sub-health is not clear. The aim of the study was thus to assess its measurement properties in individuals with sub-health in China. The data used were from a nationwide cross-sectional survey conducted among primary health care workers who were selected on the basis of convenience and voluntariness. The questionnaire was composited of 5L, Sub-Health Measurement Scale V1.0 (SHMS V1.0), social-demographic characteristics and a question assessing the presence of disease. Missing values and ceiling effects of 5L were calculated. The convergent validity of 5L utility and VAS scores was tested by assessing their correlations with SHMS V1.0 using Spearman's correlation coefficient. The known-groups validity of 5L utility and VAS scores was assessed by comparing their values between subgroups defined by SHMS V1.0 scores using the Kruskal-Wallis test. We also did an analysis in subgroups according to different regions of China. A total of 2063 respondents were included in the analysis. No missing data were observed for the 5L dimensions and only one missing value was for the VAS score. 5L showed strong overall ceiling effects (71.1%). The ceiling effects were slightly weaker on the "pain/discomfort" (82.3%) and "anxiety/depression" (79.5%) dimensions compared with the other three dimensions (nearly 100%). The 5L weakly correlated with SHMS V1.0: the correlation coefficients were mainly between 0.2 and 0.3 for the two scores. 5L was yet not sensitive in distinguishing subgroups of respondents with different levels of sub-health, especially the subgroups with adjacent health status (p > 0.05). The results of subgroup analysis were generally consistent with those of the full sample. It appears that the measurement properties of EQ-5D-5L in individuals with sub-health are not satisfactory in China. We thus should be cautious to use it in the population.