An integrated transcriptome and microbial community analysis reveals potential mechanisms for increased immune responses when replacing silybum marianum meal with soybean meal in growing lambs

Silybum marianum meal is a by-product that remains silymarin complex and is perceived as a potential-protein source. The potential and its mechanism of silybum marianum meal as a protein supplement in ruminants were evaluated by testing the growth performance, biochemical parameters, cytokine levels...

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Bibliographic Details
Published in:Frontiers in microbiology 2023-03, Vol.14, p.1093129-1093129
Main Authors: Zhang, Tianxi, Ren, Yanbo, Yang, Chao, Gebeyew, Kefyalew, Gao, Min, He, Zhixiong, Tan, Zhiliang
Format: Article
Language:English
Subjects:
cytokines
lambs
microbial community
Microbiology
silybum marianum meal
soybean meal
transcriptome
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Summary:Silybum marianum meal is a by-product that remains silymarin complex and is perceived as a potential-protein source. The potential and its mechanism of silybum marianum meal as a protein supplement in ruminants were evaluated by testing the growth performance, biochemical parameters, cytokine levels, gut transcriptome and microbial community profiles. Forty-two male Hulunbeier growing lambs (aged about 3-month-old; averaged body weight of 21.55 kg) were randomly divided into the CON (with 10% soybean meal) and SIL groups (with 10% silybum marianum meal). There was no significant difference in growth performance, feed intakes, or serum biochemical parameters between CON and SIL. The serum levels of IL-1β, TNF-α, TGF-β, HGF, and VEGF were all increased (
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2023.1093129