The role of the nucleus basalis of Meynert in neuromodulation therapy: a systematic review from the perspective of neural network oscillations

As a crucial component of the cerebral cholinergic system and the Papez circuit in the basal forebrain, dysfunction of the nucleus basalis of Meynert (NBM) is associated with various neurodegenerative disorders. However, no drugs, including existing cholinesterase inhibitors, have been shown to reve...

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Published in:Frontiers in aging neuroscience 2024-04, Vol.16, p.1376764-1376764
Main Authors: Jiao, Liwu, Kang, Huicong, Geng, Yumei, Liu, Xuyang, Wang, Mengying, Shu, Kai
Format: Article
Language:English
Subjects:
Aging Neuroscience
Alzheimer’s disease
Basal forebrain
Behavior
Brain research
Cell activation
Cholinergic transmission
Cholinesterase inhibitors
Cognition & reasoning
Cognitive ability
Deep brain stimulation
Dementia
Disease
Forebrain
Information processing
Memory
Metabolism
neural network
Neural networks
Neurodegenerative diseases
Neurological diseases
Neuromodulation
neurophysiology
Nucleus basalis
nucleus basalis of Meynert
Oscillations
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Summary:As a crucial component of the cerebral cholinergic system and the Papez circuit in the basal forebrain, dysfunction of the nucleus basalis of Meynert (NBM) is associated with various neurodegenerative disorders. However, no drugs, including existing cholinesterase inhibitors, have been shown to reverse this dysfunction. Due to advancements in neuromodulation technology, researchers are exploring the use of deep brain stimulation (DBS) therapy targeting the NBM (NBM-DBS) to treat mental and neurological disorders as well as the related mechanisms. Herein, we provided an update on the research progress on cognition-related neural network oscillations and complex anatomical and projective relationships between the NBM and other cognitive structures and circuits. Furthermore, we reviewed previous animal studies of NBM lesions, NBM-DBS models, and clinical case studies to summarize the important functions of the NBM in neuromodulation. In addition to elucidating the mechanism of the NBM neural network, future research should focus on to other types of neurons in the NBM, despite the fact that cholinergic neurons are still the key target for cell type-specific activation by DBS.
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2024.1376764