Extracellular vesicle biopotentiated hydrogels for diabetic wound healing: The art of living nanomaterials combined with soft scaffolds

Diabetic wounds (DWs) pose a major challenge for the public health system owing to their high incidence, complex pathogenesis, and long recovery time; thus, there is an urgent need to develop innovative therapies to accelerate the healing process of diabetic wounds. As natural nanovesicles, extracel...

Full description

Saved in:
Bibliographic Details
Published in:Materials today bio 2023-12, Vol.23, p.100810-100810, Article 100810
Main Authors: Yan, Zhenzhen, Zhang, Tinglin, Wang, Yuxiang, Xiao, Shichu, Gao, Jie
Format: Article
Language:English
Subjects:
Design strategy
Diabetic wounds
Extracellular vesicle
Hydrogel
Mechanism
Review
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Diabetic wounds (DWs) pose a major challenge for the public health system owing to their high incidence, complex pathogenesis, and long recovery time; thus, there is an urgent need to develop innovative therapies to accelerate the healing process of diabetic wounds. As natural nanovesicles, extracellular vesicles (EVs) are rich in sources with low immunogenicity and abundant nutritive molecules and exert potent therapeutic effects on diabetic wound healing. To avoid the rapid removal of EVs, a suitable delivery system is required for their controlled release. Owing to the advantages of high porosity, good biocompatibility, and adjustable physical and chemical properties of hydrogels, EV biopotentiated hydrogels can aid in achieving precise and favorable therapy against diabetic wounds. This review highlights the different design strategies, therapeutic effects, and mechanisms of EV biopotentiated hydrogels. We also discussed the future challenges and opportunities of using EV biopotentiated hydrogels for diabetic wound healing. Design strategies and mechanisms of EV biopotentiated hydrogels for promoting diabetic wound healing. EV, extracellular vesicle. Created by BioRender. com. [Display omitted]
ISSN:2590-0064
2590-0064
DOI:10.1016/j.mtbio.2023.100810