A new cytotoxic friedelane acid--pluricostatic acid--and other compounds from the leaves of Marila pluricostata

Bioassay-guided fractionation of the dichloromethane extract of the leaves of Marila pluricostata led to the isolation of 2alpha,3beta-dihydroxy-D:A-friedoolean-28-oic acid (pluricostatic acid), a new friedelane triterpenoid, (1), ten known triterpenoids and three sterols. Their chemical structures...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2008-11, Vol.13 (11), p.2915-2924
Main Authors: Olmedo, Dionisio A, López-Pérez, José L, del Olmo, Esther, Vásquez, Yelkaira, San Feliciano, Arturo, Gupta, Mahabir P
Format: Article
Language:English
Subjects:
2ÃŽÂ
3β- dihydroxy-D:A-friedoolean-28-oic acid
Acids
Carbon
Cell Line, Tumor
Clusiaceae
Clusiaceae - chemistry
Communication
Cytotoxicity
Drug Screening Assays, Antitumor
Gas Chromatography-Mass Spectrometry
Humans
Marila pluricostata
Models, Molecular
Plant Leaves - chemistry
Sterols
Triterpenes - chemistry
Triterpenes - isolation & purification
Triterpenes - pharmacology
Triterpenoids
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Summary:Bioassay-guided fractionation of the dichloromethane extract of the leaves of Marila pluricostata led to the isolation of 2alpha,3beta-dihydroxy-D:A-friedoolean-28-oic acid (pluricostatic acid), a new friedelane triterpenoid, (1), ten known triterpenoids and three sterols. Their chemical structures were elucidated through spectroscopic analysis. The less polar fractions, on GC/MS analysis and comparison with a MS library, resulted in the identification of twenty four sesquiterpenoids. The new triterpenoid acid 1 showed cytotoxicity against the MCF-7, H-460, and SF-268 human cancer cell lines with GI(50) values from 1.2 to 3.3 microg/mL.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules13112915