Lipidomics unveils the complexity of the lipidome in metabolic diseases

Dysregulation of lipid metabolism is responsible for pathologies of human diseases including metabolic diseases. Recent advances in lipidomics analysis allow for the targeted and untargeted identification of lipid species and for their quantification in normal and diseased conditions. Herein, this r...

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Bibliographic Details
Published in:Clinical and translational medicine 2018-01, Vol.7 (1), p.1-13
Main Authors: Lydic, Todd A., Goo, Young-Hwa
Format: Article
Language:English
Subjects:
Atherosclerosis
Clinical and Translational Cardiovascular Medicine
Lipid
Lipid droplet
Lipidome
Lipidomics
Lipoprotein
Mass spectrometry
Medicine
Medicine & Public Health
Metabolic disease
Metabolism
Review
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Summary:Dysregulation of lipid metabolism is responsible for pathologies of human diseases including metabolic diseases. Recent advances in lipidomics analysis allow for the targeted and untargeted identification of lipid species and for their quantification in normal and diseased conditions. Herein, this review provides a brief introduction to lipidomics, highlights its application to characterize the lipidome at the cellular and physiological levels under different biological conditions, and discusses the potential for the use of lipidomics in the discovery of biomarkers.
ISSN:2001-1326
2001-1326
DOI:10.1186/s40169-018-0182-9