CSF dynamics throughout the ventricular system using 4D flow MRI: associations to arterial pulsatility, ventricular volumes, and age

• Published in: Fluids and barriers of the CNS 2024-08, Vol.21 (1), p.68-11, Article 68
• Main Authors: Vikner, Tomas, Johnson, Kevin M, Cadman, Robert V, Betthauser, Tobey J, Wilson, Rachael E, Chin, Nathaniel, Eisenmenger, Laura B, Johnson, Sterling C, Rivera-Rivera, Leonardo A
• Format: Article
• Language: English
• Subjects: 4D flow MRI; Adult; Aged; Aged, 80 and over; Aging; Aging - physiology; Alzheimer's disease; Blood flow; Cardiac pulsatility; Cerebral blood flow; Cerebral Ventricles - diagnostic imaging; Cerebral Ventricles - physiology; Cerebrospinal fluid; Cerebrospinal Fluid - diagnostic imaging; Cerebrospinal Fluid - physiology; Cerebrovascular Circulation - physiology; Feasibility studies; Female; Flow dynamics; Fluid flow; Heart; Heart rate; Hemodynamics; Humans; Hydrocephalus; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Medical research; Medicine, Experimental; Middle Aged; Nervous system diseases; Neurodegenerative diseases; Neurological diseases; Neurological disorders; Pulsatile Flow - physiology; Regression analysis; Velocity; Ventricle (lateral); Ventricles (cerebral)
• ISSN: 2045-8118; 2045-8118
• DOI: 10.1186/s12987-024-00570-4

Cerebrospinal fluid (CSF) dynamics are increasingly studied in aging and neurological disorders. Models of CSF-mediated waste clearance suggest that altered CSF dynamics could play a role in the accumulation of toxic waste in the CNS, with implications for Alzheimer's disease and other proteinopathies. Therefore, approaches that enable quantitative and volumetric assessment of CSF flow velocities could be of value. In this study we demonstrate the feasibility of 4D flow MRI for simultaneous assessment of CSF dynamics throughout the ventricular system, and evaluate associations to arterial pulsatility, ventricular volumes, and age. In a cognitively unimpaired cohort (N = 43; age 41-83 years), cardiac-resolved 4D flow MRI CSF velocities were obtained in the lateral ventricles (LV), foramens of Monro, third and fourth ventricles (V3 and V4), the cerebral aqueduct (CA) and the spinal canal (SC), using a velocity encoding (venc) of 5 cm/s. Cerebral blood flow pulsatility was also assessed with 4D flow (venc = 80 cm/s), and CSF volumes were obtained from T1- and T2-weighted MRI. Multiple linear regression was used to assess effects of age, ventricular volumes, and arterial pulsatility on CSF velocities. Cardiac-driven CSF dynamics were observed in all CSF spaces, with region-averaged velocity range and root-mean-square (RMS) velocity encompassing from very low in the LVs (RMS 0.25 ± 0.08; range 0.85 ± 0.28 mm/s) to relatively high in the CA (RMS 6.29 ± 2.87; range 18.6 ± 15.2 mm/s). In the regression models, CSF velocity was significantly related to age in 5/6 regions, to CSF space volume in 2/3 regions, and to arterial pulsatility in 3/6 regions. Group-averaged waveforms indicated distinct CSF flow propagation delays throughout CSF spaces, particularly between the SC and LVs. Our findings show that 4D flow MRI enables assessment of CSF dynamics throughout the ventricular system, and captures independent effects of age, CSF space morphology, and arterial pulsatility on CSF motion.