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Effect of early vitamin D supplementation on the incidence of preeclampsia in primigravid women: a randomised clinical trial in Eastern Democratic Republic of the Congo
Previous studies have reported the association between maternal vitamin D deficiency and preeclampsia. However, the efficacy of vitamin D supplementation in reducing the occurrence of preeclampsia remains unclear. The objective of this study was to evaluate the effect of cholecalciferol supplementat...
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| Published in: | BMC pregnancy and childbirth 2024-02, Vol.24 (1), p.107-107, Article 107 |
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| creator | Kabuyanga, Richard Kabuseba Tugirimana, Pierrot Lundimu Sifa, Balungwe Balezi, Mwanga Dikete, Michel Ekanga Mitangala, Prudence Ndeba Elongi, Jean Pierre Moyene Kinenkinda, Xavier Kalume Kakoma, Jean-Baptiste Sakatolo Zambeze |
| description | Previous studies have reported the association between maternal vitamin D deficiency and preeclampsia. However, the efficacy of vitamin D supplementation in reducing the occurrence of preeclampsia remains unclear. The objective of this study was to evaluate the effect of cholecalciferol supplementation on the incidence of preeclampsia in primigravid women and its related maternal and foetal outcomes.
A single-blinded clinical trial was conducted in fourteen antenatal care health facilities in the North (Goma, Mwesso, Nyiragongo) and South Kivu (Bukavu-Panzi) provinces of the Democratic Republic of Congo from March 1, 2020, to June 30, 2021. A total of 1300 primigravid women not exceeding 16 weeks of gestation were randomised with a 1:1 ratio to either the supplemented (A) or control (B) group. Each pregnant woman (A) presenting for antenatal care received a single monthly dose of cholecalciferol (60,000 IU) orally for 6 months. The control group received no vitamin D supplementation or placebo. Serum 25(OH)D was measured at recruitment and at 34 weeks of gestation. Outcomes were assessed monthly until delivery.
The median maternal age was 21 years (14-40), while the median gestational age was 15 weeks (5.4-29.0). A significant reduction in the risk of preeclampsia [RR = 0.36 (0.19-0.69); p = 0.001] and preterm delivery [RR = 0.5 (0.32-0.78); p = 0.002] was observed in the intervention group. An RR of 0.43 [(0.27-0.67); p |
| doi_str_mv | 10.1186/s12884-024-06277-6 |
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A single-blinded clinical trial was conducted in fourteen antenatal care health facilities in the North (Goma, Mwesso, Nyiragongo) and South Kivu (Bukavu-Panzi) provinces of the Democratic Republic of Congo from March 1, 2020, to June 30, 2021. A total of 1300 primigravid women not exceeding 16 weeks of gestation were randomised with a 1:1 ratio to either the supplemented (A) or control (B) group. Each pregnant woman (A) presenting for antenatal care received a single monthly dose of cholecalciferol (60,000 IU) orally for 6 months. The control group received no vitamin D supplementation or placebo. Serum 25(OH)D was measured at recruitment and at 34 weeks of gestation. Outcomes were assessed monthly until delivery.
The median maternal age was 21 years (14-40), while the median gestational age was 15 weeks (5.4-29.0). A significant reduction in the risk of preeclampsia [RR = 0.36 (0.19-0.69); p = 0.001] and preterm delivery [RR = 0.5 (0.32-0.78); p = 0.002] was observed in the intervention group. An RR of 0.43 [(0.27-0.67); p < 0.001] was found for low birth weight. The RR for caesarean section was 0.63 [(0.52-0.75); p < 0.001]. The APGAR score at the 5th minute (p = 0.021) and the size of the newborn were significantly higher in the supplemented group (p = 0.005).
A single monthly dose (60,000 IU) of vitamin D supplementation, started in earlypregnancy, significantly reduced the incidence of preeclampsia and its maternal and foetal complications.
ISRCTN Register with ISRCTN46539495 on 17 November 2020.</description><identifier>ISSN: 1471-2393</identifier><identifier>EISSN: 1471-2393</identifier><identifier>DOI: 10.1186/s12884-024-06277-6</identifier><identifier>PMID: 38310218</identifier><language>eng</language><publisher>England: BioMed Central</publisher><subject>Adolescent ; Adult ; Apgar score ; Birth weight ; Cesarean Section ; Cholecalciferol - therapeutic use ; Clinical trials ; Democratic Republic of the Congo - epidemiology ; Dietary Supplements ; Disease ; Female ; Health facilities ; Hospitals ; Humans ; Hypertension ; Incidence ; Infant ; Infant, Newborn ; Pre-Eclampsia - epidemiology ; Pre-Eclampsia - prevention & control ; Preeclampsia ; Pregnancy ; Premature birth ; Prenatal care ; Prevention ; Supplementation ; Vitamin D ; Vitamin D Deficiency ; Vitamin deficiency ; Vitamins - therapeutic use ; Womens health ; Young Adult</subject><ispartof>BMC pregnancy and childbirth, 2024-02, Vol.24 (1), p.107-107, Article 107</ispartof><rights>2024. The Author(s).</rights><rights>2024. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-c60171bc9e612eb729dad07967860b0ea44664388872dccbac7358248193463b3</citedby><cites>FETCH-LOGICAL-c508t-c60171bc9e612eb729dad07967860b0ea44664388872dccbac7358248193463b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2925596894?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,777,781,25734,27905,27906,36993,36994,44571</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38310218$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kabuyanga, Richard Kabuseba</creatorcontrib><creatorcontrib>Tugirimana, Pierrot Lundimu</creatorcontrib><creatorcontrib>Sifa, Balungwe</creatorcontrib><creatorcontrib>Balezi, Mwanga</creatorcontrib><creatorcontrib>Dikete, Michel Ekanga</creatorcontrib><creatorcontrib>Mitangala, Prudence Ndeba</creatorcontrib><creatorcontrib>Elongi, Jean Pierre Moyene</creatorcontrib><creatorcontrib>Kinenkinda, Xavier Kalume</creatorcontrib><creatorcontrib>Kakoma, Jean-Baptiste Sakatolo Zambeze</creatorcontrib><title>Effect of early vitamin D supplementation on the incidence of preeclampsia in primigravid women: a randomised clinical trial in Eastern Democratic Republic of the Congo</title><title>BMC pregnancy and childbirth</title><addtitle>BMC Pregnancy Childbirth</addtitle><description>Previous studies have reported the association between maternal vitamin D deficiency and preeclampsia. However, the efficacy of vitamin D supplementation in reducing the occurrence of preeclampsia remains unclear. The objective of this study was to evaluate the effect of cholecalciferol supplementation on the incidence of preeclampsia in primigravid women and its related maternal and foetal outcomes.
A single-blinded clinical trial was conducted in fourteen antenatal care health facilities in the North (Goma, Mwesso, Nyiragongo) and South Kivu (Bukavu-Panzi) provinces of the Democratic Republic of Congo from March 1, 2020, to June 30, 2021. A total of 1300 primigravid women not exceeding 16 weeks of gestation were randomised with a 1:1 ratio to either the supplemented (A) or control (B) group. Each pregnant woman (A) presenting for antenatal care received a single monthly dose of cholecalciferol (60,000 IU) orally for 6 months. The control group received no vitamin D supplementation or placebo. Serum 25(OH)D was measured at recruitment and at 34 weeks of gestation. Outcomes were assessed monthly until delivery.
The median maternal age was 21 years (14-40), while the median gestational age was 15 weeks (5.4-29.0). A significant reduction in the risk of preeclampsia [RR = 0.36 (0.19-0.69); p = 0.001] and preterm delivery [RR = 0.5 (0.32-0.78); p = 0.002] was observed in the intervention group. An RR of 0.43 [(0.27-0.67); p < 0.001] was found for low birth weight. The RR for caesarean section was 0.63 [(0.52-0.75); p < 0.001]. The APGAR score at the 5th minute (p = 0.021) and the size of the newborn were significantly higher in the supplemented group (p = 0.005).
A single monthly dose (60,000 IU) of vitamin D supplementation, started in earlypregnancy, significantly reduced the incidence of preeclampsia and its maternal and foetal complications.
ISRCTN Register with ISRCTN46539495 on 17 November 2020.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Apgar score</subject><subject>Birth weight</subject><subject>Cesarean Section</subject><subject>Cholecalciferol - therapeutic use</subject><subject>Clinical trials</subject><subject>Democratic Republic of the Congo - epidemiology</subject><subject>Dietary Supplements</subject><subject>Disease</subject><subject>Female</subject><subject>Health facilities</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Incidence</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Pre-Eclampsia - epidemiology</subject><subject>Pre-Eclampsia - prevention & control</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Premature birth</subject><subject>Prenatal care</subject><subject>Prevention</subject><subject>Supplementation</subject><subject>Vitamin D</subject><subject>Vitamin D Deficiency</subject><subject>Vitamin deficiency</subject><subject>Vitamins - 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Academic</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>BMC pregnancy and childbirth</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kabuyanga, Richard Kabuseba</au><au>Tugirimana, Pierrot Lundimu</au><au>Sifa, Balungwe</au><au>Balezi, Mwanga</au><au>Dikete, Michel Ekanga</au><au>Mitangala, Prudence Ndeba</au><au>Elongi, Jean Pierre Moyene</au><au>Kinenkinda, Xavier Kalume</au><au>Kakoma, Jean-Baptiste Sakatolo Zambeze</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of early vitamin D supplementation on the incidence of preeclampsia in primigravid women: a randomised clinical trial in Eastern Democratic Republic of the Congo</atitle><jtitle>BMC pregnancy and childbirth</jtitle><addtitle>BMC Pregnancy Childbirth</addtitle><date>2024-02-03</date><risdate>2024</risdate><volume>24</volume><issue>1</issue><spage>107</spage><epage>107</epage><pages>107-107</pages><artnum>107</artnum><issn>1471-2393</issn><eissn>1471-2393</eissn><abstract>Previous studies have reported the association between maternal vitamin D deficiency and preeclampsia. However, the efficacy of vitamin D supplementation in reducing the occurrence of preeclampsia remains unclear. The objective of this study was to evaluate the effect of cholecalciferol supplementation on the incidence of preeclampsia in primigravid women and its related maternal and foetal outcomes.
A single-blinded clinical trial was conducted in fourteen antenatal care health facilities in the North (Goma, Mwesso, Nyiragongo) and South Kivu (Bukavu-Panzi) provinces of the Democratic Republic of Congo from March 1, 2020, to June 30, 2021. A total of 1300 primigravid women not exceeding 16 weeks of gestation were randomised with a 1:1 ratio to either the supplemented (A) or control (B) group. Each pregnant woman (A) presenting for antenatal care received a single monthly dose of cholecalciferol (60,000 IU) orally for 6 months. The control group received no vitamin D supplementation or placebo. Serum 25(OH)D was measured at recruitment and at 34 weeks of gestation. Outcomes were assessed monthly until delivery.
The median maternal age was 21 years (14-40), while the median gestational age was 15 weeks (5.4-29.0). A significant reduction in the risk of preeclampsia [RR = 0.36 (0.19-0.69); p = 0.001] and preterm delivery [RR = 0.5 (0.32-0.78); p = 0.002] was observed in the intervention group. An RR of 0.43 [(0.27-0.67); p < 0.001] was found for low birth weight. The RR for caesarean section was 0.63 [(0.52-0.75); p < 0.001]. The APGAR score at the 5th minute (p = 0.021) and the size of the newborn were significantly higher in the supplemented group (p = 0.005).
A single monthly dose (60,000 IU) of vitamin D supplementation, started in earlypregnancy, significantly reduced the incidence of preeclampsia and its maternal and foetal complications.
ISRCTN Register with ISRCTN46539495 on 17 November 2020.</abstract><cop>England</cop><pub>BioMed Central</pub><pmid>38310218</pmid><doi>10.1186/s12884-024-06277-6</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | BMC pregnancy and childbirth, 2024-02, Vol.24 (1), p.107-107, Article 107 |
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| source | PubMed (Medline); Publicly Available Content Database |
| subjects | Adolescent Adult Apgar score Birth weight Cesarean Section Cholecalciferol - therapeutic use Clinical trials Democratic Republic of the Congo - epidemiology Dietary Supplements Disease Female Health facilities Hospitals Humans Hypertension Incidence Infant Infant, Newborn Pre-Eclampsia - epidemiology Pre-Eclampsia - prevention & control Preeclampsia Pregnancy Premature birth Prenatal care Prevention Supplementation Vitamin D Vitamin D Deficiency Vitamin deficiency Vitamins - therapeutic use Womens health Young Adult |
| title | Effect of early vitamin D supplementation on the incidence of preeclampsia in primigravid women: a randomised clinical trial in Eastern Democratic Republic of the Congo |
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