Anti-Ascaris immunoglobulin E associated with bronchial hyper-reactivity in 9-year-old rural Bangladeshi children

Studies have addressed the immunomodulatory effects of helminths and their protective effects upon asthma. However, anti-Ascaris IgE has been reported to be associated with an increased risk of asthma symptoms. We examined the association between serum levels of anti-Ascaris IgE and bronchial hyper-...

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Bibliographic Details
Published in:Allergology international 2016-04, Vol.65 (2), p.141-146
Main Authors: Takeuchi, Haruko, Khan, Al Fazal, Yunus, Mohammad, Hasan, Mohammad Imrul, Hawlader, Mohammad Delwer Hossain, Takanashi, Sayaka, Kano, Hirotsugu, Zaman, Khalequz, Chowdhury, Hafizur R., Wagatsuma, Yukiko, Nakahara, Shinji, Iwata, Tsutomu
Format: Article
Language:English
Subjects:
Animals
Antibodies, Helminth - blood
Antibodies, Helminth - immunology
Antigen specific IgE
Ascaris - immunology
Bangladesh - epidemiology
Bronchial hyper-responsiveness
Bronchial Hyperreactivity - diagnosis
Bronchial Hyperreactivity - epidemiology
Bronchial Hyperreactivity - immunology
Bronchial Provocation Tests
Child
Childhood asthma
Female
Humans
Immunoglobulin E - blood
Immunoglobulin E - immunology
Lung function tests
Male
Nematode infections
Odds Ratio
Respiratory Function Tests
Respiratory Sounds
Rural Population
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Summary:Studies have addressed the immunomodulatory effects of helminths and their protective effects upon asthma. However, anti-Ascaris IgE has been reported to be associated with an increased risk of asthma symptoms. We examined the association between serum levels of anti-Ascaris IgE and bronchial hyper-responsiveness (BHR) in children living in rural Bangladesh. Serum anti-Ascaris IgE level was measured and the BHR test done in 158 children aged 9 years selected randomly from a general population of 1705 in the Matlab Health and Demographic Surveillance Area of the International Centre for Diarrhoeal Disease Research, Bangladesh. We investigated wheezing symptoms using a questionnaire from the International Study of Asthma and Allergies in Childhood. BHR tests were successfully done on 152 children (108 ‘current wheezers’; 44 ‘never-wheezers’). We examined the association between anti-Ascaris IgE level and wheezing and BHR using multiple logistic regression analyses. Of 108 current-wheezers, 59 were BHR-positive; of 44 never-wheezers, 32 were BHR-negative. Mean anti-Ascaris IgE levels were significantly higher (12.51 UA/ml; 95% confidence interval (CI), 9.21–17.00) in children with current wheezing with BHR-positive than in those of never-wheezers with BHR-negative (3.89; 2.65–5.70; t test, p 
ISSN:1323-8930
1440-1592
DOI:10.1016/j.alit.2015.07.002