The effect of cold plasma on the treatment of external otitis: an experimental study in rats

In this paper we investigate the influence of cold plasma as novel method on the external otitis treatment which is a frequent cause of earache. 24 infected external auditory canals in 24 rats were categorized in four experimental groups including control, plasma exposed, ciprofloxacin drug and mixe...

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Bibliographic Details
Published in:AMB Express 2024-09, Vol.14 (1), p.101-7, Article 101
Main Authors: Taghizade, Tayebe, Akbarzadeh-Baghban, Alireza, Navab Safa, Nasrin
Format: Article
Language:English
Subjects:
Antibiotics
Biomedical and Life Sciences
Biotechnology
Ciprofloxacin
Cold
Cold plasma
Cold plasmas
Cold treatment
Colonies
Dielectric barrier discharge
Ear
Ear canal
Effusion
External otitis
Life Sciences
Microbial Genetics and Genomics
Microbiology
Original
Original Article
Otitis
Plasma
Rat
Statistical analysis
Swelling
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Summary:In this paper we investigate the influence of cold plasma as novel method on the external otitis treatment which is a frequent cause of earache. 24 infected external auditory canals in 24 rats were categorized in four experimental groups including control, plasma exposed, ciprofloxacin drug and mixed of plasma-ciprofloxacin groups. In plasma group, dielectric barrier discharge was employed as the source of cold plasma in 5 days. All rats were observed with otoscope daily and a scoring system was used to evaluate swelling and effusion of the ear canal. Number of colonies in microbiological culture were counted in each group during the first 5 days after treatment. For the multiple group comparisons of swelling and effusion measured in the external auditory canal, Kruskal–Wallis analysis was applied and one-way anova and Kruskal–Wallis analysis was used for the statistical analysis of the results of the cultures in different days. Also, Tukey and Mann–Whitney tests was applied for multiple comparisons. Our findings show that swelling and effusion were obviously reduced in plasma group compared to control group ( P  
ISSN:2191-0855
2191-0855
DOI:10.1186/s13568-024-01748-7