Protective effects of celery juice in treatments with Doxorubicin

The aim of this work was to investigate possible protective effect of celery juice in doxorubicin treatment. The following biochemical parameters were determined: content of reduced glutathione, activities of catalase, xanthine oxidase, glutathione peroxidase, peroxidase, and lipid peroxidation inte...

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Published in:Molecules (Basel, Switzerland) Switzerland), 2009-04, Vol.14 (4), p.1627-1638
Main Authors: Kolarovic, Jovanka, Popovic, Mira, Mikov, Momir, Mitic, Radoslav, Gvozdenovic, Ljiljana
Format: Article
Language:English
Subjects:
Animals
Antioxidants
Antioxidants - chemistry
Antioxidants - pharmacology
Apium graveolens - anatomy & histology
Apium graveolens - chemistry
Blood Proteins - metabolism
Bone marrow
Cancer therapies
Cardiotoxicity
Catalase
Catalase - metabolism
Celery juice
Chemotherapy
Cytoprotection
Doxorubicin
Doxorubicin - pharmacology
Doxorubicin - toxicity
Drugs
Glutathione - metabolism
Glutathione Peroxidase - metabolism
Lipid Peroxidation
Lipids
Liver
Liver - drug effects
Liver - enzymology
Metabolism
Mice
Pancreatic cancer
Peroxidase - metabolism
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plants, Medicinal - chemistry
Proteins
Reduced glutathione
Toxicity
Xanthine Oxidase - metabolism
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Summary:The aim of this work was to investigate possible protective effect of celery juice in doxorubicin treatment. The following biochemical parameters were determined: content of reduced glutathione, activities of catalase, xanthine oxidase, glutathione peroxidase, peroxidase, and lipid peroxidation intensity in liver homogenate and blood hemolysate. We examined influence of diluted pure celery leaves and roots juices and their combinations with doxorubicine on analyzed biochemical parameters. Celery roots and leaves juices influenced the examined biochemical parameters and showed protective effects when applied with doxorubicine.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules14041627