Validity of Xiphophorus fish as models for human disease

Platyfish and swordtails of the genus Xiphophorus provide a well-established model for melanoma research and have become well known for this feature. Recently, modelling approaches for other human diseases in Xiphophorus have been developed or are emerging. This Review provides a comprehensive summa...

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Bibliographic Details
Published in:Disease models & mechanisms 2024-01, Vol.17 (1)
Main Authors: Schartl, Manfred, Lu, Yuan
Format: Article
Language:English
Subjects:
Animals
cancer
Cyprinodontiformes
emerging models
epistasis
expression dysregulation
Humans
hybrid incompatibility
Melanoma
obesity
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Summary:Platyfish and swordtails of the genus Xiphophorus provide a well-established model for melanoma research and have become well known for this feature. Recently, modelling approaches for other human diseases in Xiphophorus have been developed or are emerging. This Review provides a comprehensive summary of these models and discusses how findings from basic biological and molecular studies and their translation to medical research demonstrate that Xiphophorus models have face, construct and predictive validity for studying a broad array of human diseases. These models can thus improve our understanding of disease mechanisms to benefit patients.
ISSN:1754-8403
1754-8411
DOI:10.1242/dmm.050382