The Interplay among miRNAs, Major Cytokines, and Cancer-Related Inflammation

• Published in: Molecular therapy. Nucleic acids 2020-06, Vol.20, p.606-620
• Main Authors: Chakraborty, Chiranjib, Sharma, Ashish Ranjan, Sharma, Garima, Lee, Sang-Soo
• Format: Article
• Language: English
• Subjects: cancer; cytokines; inflammation; miRNA; tumor microenvironment
• ISSN: 2162-2531; 2162-2531
• DOI: 10.1016/j.omtn.2020.04.002

Inflammation is closely related with the progression of cancer and is an indispensable component that orchestrates the tumor microenvironment. Studies suggest that different mediator and cellular effectors, including cytokines (interleukins, tumor necrosis factor-α [TNF-α], transforming growth factor-β [TGF-β], and granulocyte macrophage colony-stimulating factor [GM-CSF]), chemokines, as well as some transcription factors (nuclear factor κB [NF-κB], signal transducer and activator of transcription 3 [STAT3], hypoxia-inducible factor-1α [HIF1α]), play a crucial role during cancer-related inflammation (CRI). MicroRNAs (miRNAs) are the key components of cellular physiology. They play notable roles during posttranscriptional gene regulation and, thus, might have a potential role in controlling the inflammatory cascade during cancer progression. Taking into consideration the role identified for miRNAs in relation to inflammatory cytokines, we have tried to review their participation in neoplastic progression. Additionally, the involvement of miRNAs with some important transcription factors (NF-κB, STAT3, HIF1α) and proteins (cyclooxygenase-2 [COX-2], inducible nitric oxide synthase [iNOS]) closely associated with inflammation during cancer has also been discussed. A clear insight into the responsibility of miRNAs in cytokine signaling and inflammation related to CRI could project them as new therapeutic molecules, which could lead to improved treatment of CRI in the near future. [Display omitted] Cancer is a public health issue of serious concern throughout the world. MicroRNAs (miRNAs) are involved with the regulation of posttranscriptional gene regulation and thus might participate in the neoplastic progression. miRNAs might be involved in the regulation of inflammatory cytokines, transcription factors (NF-κB, STAT3, HIF1α), and inflammatory proteins (COX-2, iNOS), closely associated with inflammation during cancer.