Ocular Manifestations of Alzheimer’s and Other Neurodegenerative Diseases: The Prospect of the Eye as a Tool for the Early Diagnosis of Alzheimer’s Disease

Dementia, including Alzheimer’s disease (AD), is a major disorder, leading to several ocular manifestations amongst the elderly population. These visual disorders may be due to retinal nerve degenerative changes, including nerve fibre layer thinning, degeneration of retinal ganglion cells, and chang...

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Bibliographic Details
Published in:Journal of ophthalmology 2018-01, Vol.2018 (2018), p.1-12
Main Authors: Pintor, Jesús, Colligris, Basilio, Pérez de Lara, María Jesús, Colligris, Pade
Format: Article
Language:English
Subjects:
Advertising executives
Age
Alzheimer's disease
Biomarkers
Brain
Clinical trials
Dementia
Development and progression
Diagnosis
Disease
Eye diseases
Glaucoma
Hypotheses
Macular degeneration
Metabolism
Metabolites
Nervous system
Ocular manifestations of general diseases
Older people
Optics
PET imaging
Protein binding
Proteins
Retina
Review
Type 2 diabetes
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Summary:Dementia, including Alzheimer’s disease (AD), is a major disorder, leading to several ocular manifestations amongst the elderly population. These visual disorders may be due to retinal nerve degenerative changes, including nerve fibre layer thinning, degeneration of retinal ganglion cells, and changes to vascular parameters. There is no cure for Alzheimer’s, but medicines can slow down the development of many of the classic symptoms, such as loss of memory and communication skills, mood swings, and depression. The disease diagnosis is difficult, and it is only possible through PET scans of the brain, detecting evidence of the accumulation of amyloid and tau. PET is expensive and invasive, requiring the injection of radioactive tracers, which bind with these proteins and glow during scanning. Recently, scientists developed promising eye-scan techniques that may detect Alzheimer’s disease at its earliest stage, before major symptoms appear, leading to improved management of the disease symptoms. In this review, we are discussing the visual abnormalities of Alzheimer’s and other neurodegenerative diseases, focused on ocular functional-visual-structural biomarkers, retinal pathology, and potential novel diagnostic tools.
ISSN:2090-004X
2090-0058
DOI:10.1155/2018/8538573