Autologous concentrated growth factor mediated accelerated bone healing in root-end microsurgery: A multicenter randomized clinical trial

• Published in: Regenerative therapy 2023-12, Vol.24, p.377-384
• Main Authors: Yahata, Yoshio, Handa, Keisuke, Ohkura, Naoto, Okamoto, Motoki, Ohshima, Jun, Itoh, Shusaku, Kawashima, Nobuyuki, Tanaka, Toshinori, Sato, Nobuya, Noiri, Yuichiro, Hayashi, Mikako, Okiji, Takashi, Saito, Masahiro
• Format: Article
• Language: English
• Subjects: Concentrated growth factor; Multicenter clinical trial; Original; Periapical; Regenerative medicine; Root-end microsurgery
• ISSN: 2352-3204; 2352-3204
• DOI: 10.1016/j.reth.2023.08.006

Concentrated growth factor (CGF) is a new-generation autologous platelet concentrate that promotes tissue regeneration and has anti-inflammatory properties. This randomized multicenter trial aimed to evaluate the effects of CGF on bone healing in combination with root-end microsurgery. Healthy adult patients indicated for root-end microsurgery were randomly assigned to either the CGF or control (no CGF implantation) groups. CGF was implanted into the bone cavity after root-end filling with mineral trioxide aggregate. Clinical and periapical radiographic evaluations were conducted at 1, 3, 6, and 12 months postoperatively, with follow-up cone-beam computed tomography (CBCT) at 6 months. The lesion volume reduction rate was calculated based on data from the preoperative and follow-up CBCT images. A total of 24 patients were enrolled. The treatment success rate was 91.7% and 83.3% on 12-month periapical radiography and 6-month CBCT, respectively, without a significant difference between the two groups. The lesion volume reduction rate in the CGF group (75.6%) was significantly higher than that in the control (61.0%) group. Autologous CGF in conjunction with root-end microsurgery accelerated lesion reduction as observed on CBCT. Administering autologous blood products to stimulate healing in addition to removing the source of infection appears to be a promising treatment option for root-end microsurgery. •This randomized trial took place at four dental university hospitals in Japan.•Adjunctive use of autologous blood products in root-end microsurgery was examined.•Using concentrated growth factor helps accelerate alveolar bone healing.•Use of concentrated growth factor does not increase postoperative pain.•Administering autologous blood products is a promising option to stimulate healing.