Mitochondrial Dysfunction and Chronic Liver Disease

Mitochondria are generally considered the powerhouse of the cell, a small subcellular organelle that produces most of the cellular energy in the form of adenosine triphosphate (ATP). In addition, mitochondria are involved in various biological functions, such as biosynthesis, lipid metabolism, oxida...

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Bibliographic Details
Published in:Current issues in molecular biology 2022-07, Vol.44 (7), p.3156-3165
Main Authors: Zhang, Chunyan, Zhao, Yabin, Yu, Mengli, Qin, Jianru, Ye, Bingyu, Wang, Qiwen
Format: Article
Language:English
Subjects:
alcoholic fatty liver
drug-induced liver injury
hepatocellular carcinoma
mitochondrial dysfunction
non-alcoholic fatty liver
Review
viral hepatitis
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Summary:Mitochondria are generally considered the powerhouse of the cell, a small subcellular organelle that produces most of the cellular energy in the form of adenosine triphosphate (ATP). In addition, mitochondria are involved in various biological functions, such as biosynthesis, lipid metabolism, oxidative phosphorylation, cell signal transduction, and apoptosis. Mitochondrial dysfunction is manifested in different aspects, like increased mitochondrial reactive oxygen species (ROS), mitochondrial DNA (mtDNA) damage, adenosine triphosphate (ATP) synthesis disorder, abnormal mitophagy, as well as changes in mitochondrial morphology and structure. Mitochondrial dysfunction is related to the occurrence and development of various chronic liver diseases, including hepatocellular carcinoma (HCC), viral hepatitis, drug-induced liver injury (DILI), alcoholic fatty liver (AFL), and non-alcoholic fatty liver (NAFL). In this review, we summarize and discuss the role and mechanisms of mitochondrial dysfunction in chronic liver disease, focusing on and discussing some of the latest studies on mitochondria and chronic liver disease.
ISSN:1467-3045
1467-3037
1467-3045
DOI:10.3390/cimb44070218