Soluble ST2 and risk of cognitive impairment after acute ischemic stroke: a prospective observational study

Soluble suppression of tumorigenesis-2 (sST2) was reported to be associated with cognitive performance and risk of incident stroke. However, the impact of sST2 on cognitive function after ischemic stroke is unclear. We aimed to assess the association of sST2 and cognitive impairment at 3 months in a...

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Bibliographic Details
Published in:BMC geriatrics 2021-05, Vol.21 (1), p.330-330, Article 330
Main Authors: Zhu, Yinwei, Fang, Chongquan, Zhang, Qi, Lu, Yaling, Zhang, Rui, Wang, Aili, Bu, Xiaoqing, Zhang, Jintao, Ju, Zhong, Zhang, Yonghong, Xu, Tan, Zhong, Chongke
Format: Article
Language:English
Subjects:
Age
Aged
Anticoagulants
Antihypertensives
Biomarkers
Brain Ischemia - complications
Brain Ischemia - diagnosis
Brain Ischemia - epidemiology
Cardiovascular disease
China - epidemiology
Cognition disorders
Cognitive ability
Cognitive Dysfunction - diagnosis
Cognitive Dysfunction - epidemiology
Cognitive Dysfunction - etiology
Cognitive impairment
Complications and side effects
Cytokines
Diabetes
Education
Enrollments
Geriatrics
Health aspects
Heart failure
Humans
Hypertension
Interleukin-1 Receptor-Like 1 Protein
Ischemia
Ischemic Stroke
Measurement
Mini-mental state examination
Montreal cognitive assessment
Neuropsychological Tests
Observational studies
Older people
Plasma
Reclassification
Regression analysis
Risk factors
sST2
Statistical analysis
Stroke
Stroke (Disease)
Stroke - complications
Stroke - diagnosis
Stroke - epidemiology
Trends
Tumorigenesis
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Summary:Soluble suppression of tumorigenesis-2 (sST2) was reported to be associated with cognitive performance and risk of incident stroke. However, the impact of sST2 on cognitive function after ischemic stroke is unclear. We aimed to assess the association of sST2 and cognitive impairment at 3 months in acute ischemic stroke patients. Baseline plasma sST2 levels were measured in 619 ischemic stroke patients (mean age: 60.0 ± 10.5 years) from 7 participating hospitals of the China Antihypertensive Trial in Acute Ischemic Stroke. Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE) were used to assess cognitive status. Cognitive impairment was defined as a MoCA score 
ISSN:1471-2318
1471-2318
DOI:10.1186/s12877-021-02288-6