Ferritinophagy, a form of autophagic ferroptosis: New insights into cancer treatment

Ferritinophagy, a form of autophagy, is also an important part of ferroptosis, a type of regulated cell death resulting from abnormal iron metabolism involving the production of reactive oxygen species. As ferroptosis, autophagy and cancer have been revealed, ferritinophagy has attracted increasing...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in pharmacology 2022-10, Vol.13, p.1043344-1043344
Main Authors: Sun, Kai, Li, Chenyuan, Liao, Shichong, Yao, Xinrui, Ouyang, Yang, Liu, Yi, Wang, Zhong, Li, Zhiyu, Yao, Feng
Format: Article
Language:English
Subjects:
autophagy
cancer
ferritinophagy
ferroptosis
iron
Pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Ferritinophagy, a form of autophagy, is also an important part of ferroptosis, a type of regulated cell death resulting from abnormal iron metabolism involving the production of reactive oxygen species. As ferroptosis, autophagy and cancer have been revealed, ferritinophagy has attracted increasing attention in cancer development. In this review, we discuss the latest research progress on ferroptosis, autophagy-associated ferroptosis led by ferritinophagy, the regulators of ferritinophagy and promising cancer treatments that target ferritinophagy. Ferritinophagy is at the intersection of ferroptosis and autophagy and plays a significant role in cancer development. The discussed studies provide new insights into the mechanisms of ferritinophagy and promising related treatments for cancer.
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2022.1043344