The effect of short term peripheral parenteral nutrition on treatment outcomes and mortality in critically ill pediatric canine patients

• Published in: Irish Veterinary Journal 2021-06, Vol.74 (1), p.1-15, Article 15
• Main Authors: Flores Dueñas, Cesar Augusto, Gaxiola Camacho, Soila Maribel, Montaño Gómez, Martin Francisco, Villa Angulo, Rafael, Enríquez Verdugo, Idalia, Rentería Evangelista, Tomás, Pérez Corrales, José Ascención, Rodríguez Gaxiola, Miguel Ángel
• Format: Article
• Language: English
• Subjects: Amino acids; Animals; Catheters; Complications; Critically ill; Data collection; Disease; Enteral nutrition; Food; Glucose; Hospital stay; Hospitalization; Hospitals; Hydration; Infections; Length of stay; Metabolism; Mortality; Nutrition research; Parenteral nutrition; Pediatrics; Peripheral parenteral nutrition; Phlebitis; Software
• ISSN: 2046-0481; 0368-0762; 2046-0481
• DOI: 10.1186/s13620-021-00194-2

Background Peripheral parenteral nutrition (PPN) is increasingly considered as an alternative to central parenteral nutrition (CPN) given the higher cost and more frequent clinical complications associated with the latter. However, the assessment of potential risks and benefits of PPN in critically ill pediatric canine patients has not been extensively performed. In this study, we aimed to explore the effect of short-term, hypocaloric PPN on weight loss, length of hospital stay, the incidence of complications, adverse effects, and mortality in critically ill pediatric canine patients. Results Between August 2015 and August 2018, a total of 59 critically ill pediatric canine patients aged from 1 to 6 months admitted at the Veterinary Sciences Research Institute of the Autonomous University of Baja California were included in this non-randomized clinical trial. Canine pediatric patients were initially allocated to 3 groups: 11 in group 1 receiving parenteral nutrition (PN) supplementation equivalent to 40% of the resting energy requirement (RER), 12 in group 2 receiving supplementation of 50% of the RER, and 36 in group 3 receiving no PN supplementation. After establishing that there was no significant difference between 40 and 50% of PN supplementation, these groups were not separated for downstream analysis. Similar lengths of hospital stays were noted among study subjects who received PN supplementation and those who did not (4.3 ± 1.5 vs. 5.0 ± 1.5, days, p = 0.097). No metabolic-, sepsis- or phlebitis-related complications were observed in any animal in the PPN supplemented group. Higher mortality (19.4% vs. 0%, p = 0.036), and a greater percentage of weight loss (9.24% vs. 0%, p