The ameliorating effects of Vitamin E on hepatotoxicity of ecstasy

The production of stress oxidative condition in body which is caused by consumption of ecstasy (3,4-methylenedioxymethamphetamine [MDMA]) leads to a liver damage. As an antioxidant, Vitamin E can protect cells and tissues against the deleterious effects of free radicals. This study evaluates the pro...

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Bibliographic Details
Published in:Journal of research in medical sciences 2020, Vol.25 (1), p.91-91
Main Authors: Javanmard, Masoumeh Zirak, Meghrazi, Khadije, Ghafori, Sayed Soran, Karimipour, Mojtaba
Format: Article
Language:English
Subjects:
Ecstasy
Enzymes
hepatotoxicity
Liver
Morphology
Original
stress oxidative
Vitamin E
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Summary:The production of stress oxidative condition in body which is caused by consumption of ecstasy (3,4-methylenedioxymethamphetamine [MDMA]) leads to a liver damage. As an antioxidant, Vitamin E can protect cells and tissues against the deleterious effects of free radicals. This study evaluates the protective effects of Vitamin E on MDMA induced liver toxicity. Twenty-eight male albino mice were randomly assigned to four equal groups. Group 1 received saline (control), Group 2 received MDMA and saline, Group 3 received MDMA, and Vitamin E and Group 4 received Vitamin E. MDMA was injected with single daily dose, three sequential days/week for 5 weeks. At the end of the period, blood samples were collected for a biochemical analysis and then the mice were sacrificed by cervical dislocation for histopathological and biochemical examinations of liver. The administration of Vitamin E attenuated the increased levels of alanine transaminase, aspartate transaminase, and alkaline phosphatase enzymes in serum. Vitamin E treatments significantly restored endogenous antioxidant enzymes (reduced glutathione and superoxide dismutase enzyme) activities as compared with MDMA-treated animals. Histological examination of liver revealed significant morphological tissue injuries in hepatocytes after MDMA being used, but in coadministration of vitamin E and MDMA, these morphological alterations reduced. The study showed that MDMA administration has adverse effects on the liver. Vitamin E lessened the deleterious impact considerably.
ISSN:1735-1995
1735-7136
DOI:10.4103/jrms.JRMS_496_19