Integrative Bioinformatics Analysis of The Cell Division Cycle and Ribosomal Pathways in The Rat Varicocele: Implications for Drug Discovery

Objective:Varicocele is a common cause of male infertility, affecting a substantial proportion of infertile men. Recent studies have employed transcriptomic analysis to identify candidate genes that may be implicated in the pathogenesis of this condition. Accordingly, this study sought to leverage r...

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Bibliographic Details
Published in:Cell journal (Yakhteh) 2023-10, Vol.25 (10), p.727-737
Main Authors: Nasr-Esfahani, Ali, Motlagh, Ali Valipour, Adib, Minoo, kosar Pashaei, Mohammad Hossein Nasr-Esfahani
Format: Article
Language:English
Subjects:
Animal tissues
Bioinformatics
Cell division
cell division cycle
Dexamethasone
Drugs
Gene expression
Genes
Infertility
Networks
Original
Pathogenesis
Protein interaction
Proteins
Ribonucleic acid
RNA
rna-seq
Transcriptomics
varicocele
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Summary:Objective:Varicocele is a common cause of male infertility, affecting a substantial proportion of infertile men. Recent studies have employed transcriptomic analysis to identify candidate genes that may be implicated in the pathogenesis of this condition. Accordingly, this study sought to leverage rat gene expression profiling, along with protein-protein interaction networks, to identify key regulatory genes, related pathways, and potentially effective drugs for the treatment of varicocele. Materials and Methods:In this in-silico study, differentially expressed genes (DEGs) from the testicular tissue of 3 rats were screened using the edgeR package in R software and the results were compared to 3 rats in the control group. Data was obtained from GSE139447. Setting a -11 and P
ISSN:2228-5806
2228-5814
DOI:10.22074/cellj.2023.2004771.1329