Gut dysbiosis in mice genetically selected for low antibody production

Dysbiosis is linked to the cause of several human diseases, many of which having an immunity related component. This work investigated whether mice genetically selected for low or high antibody production display differences in intestinal bacterial communities, and consisted in the comparison of fec...

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Bibliographic Details
Published in:Gut pathogens 2017-08, Vol.9 (1), p.43-43, Article 43
Main Authors: da Silva Santos, Ana Carolina, Jensen, José Ricardo, de Oliveira, Silvio Luis, Rodrigues, Josias
Format: Article
Language:English
Subjects:
Animals
Antibodies
Antibody
Antigens
Bacteria
Bacteroidetes
Deoxyribonucleic acid
Digestive system
DNA
Dysbacteriosis
Dysbiosis
Feces
Firmicutes
Gastrointestinal tract
Gel electrophoresis
Genetic aspects
Immune system
Infections
Inflammatory bowel disease
Intestine
Leprosy
Microbiome
Physiological aspects
Prevotellaceae
Rats
Rattus
Ruminococcaceae
Short Report
Viral antibodies
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Summary:Dysbiosis is linked to the cause of several human diseases, many of which having an immunity related component. This work investigated whether mice genetically selected for low or high antibody production display differences in intestinal bacterial communities, and consisted in the comparison of fecal 16SV6-V8 rDNA PCR amplicons resolved by temperature gradient gel electrophoresis (TGGE) of five each of low (LIII) and high (HIII) antibody producing mice. 16SV6 rDNA amplicons of 2 mice from each line were sequenced. LIII mice were grouped in a single TGGE cluster, displayed a low α-diversity, and were distinguished by low Firmicutes/Bacteroidetes ratio. The results suggest that genetically driven low antibody production in mice is associated with gut dysbiosis.
ISSN:1757-4749
1757-4749
DOI:10.1186/s13099-017-0193-x