Evaluation of Beneficial Metabolic Effects of Berries in High-Fat Fed C57BL/6J Mice

Objective. The aim of the study was to screen eight species of berries for their ability to prevent obesity and metabolic abnormalities associated with type 2 diabetes. Methods. C57BL/6J mice were assigned the following diets for 13 weeks: low-fat diet, high-fat diet or high-fat diet supplemented (2...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Nutrition and Metabolism 2014-01, Vol.2014 (2014), p.70-81
Main Authors: Holm, Cecilia, Sterner, Olov, Blanco, Narda, Axling, Ulrika, Heyman, Lovisa, Berger, Karin
Format: Article
Language:English
Subjects:
Berries
Care and treatment
Complications and side effects
Health aspects
Health Sciences
Hälsovetenskap
Medical and Health Sciences
Medicin och hälsovetenskap
Nutrition and Dietetics
Nutritional aspects
Näringslära
Obesity
Prevention
Type 2 diabetes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective. The aim of the study was to screen eight species of berries for their ability to prevent obesity and metabolic abnormalities associated with type 2 diabetes. Methods. C57BL/6J mice were assigned the following diets for 13 weeks: low-fat diet, high-fat diet or high-fat diet supplemented (20%) with lingonberry, blackcurrant, bilberry, raspberry, açai, crowberry, prune or blackberry. Results. The groups receiving a high-fat diet supplemented with lingonberries, blackcurrants, raspberries or bilberries gained less weight and had lower fasting insulin levels than the control group receiving high-fat diet without berries. Lingonberries, and also blackcurrants and bilberries, significantly decreased body fat content, hepatic lipid accumulation, and plasma levels of the inflammatory marker PAI-1, as well as mediated positive effects on glucose homeostasis. The group receiving açai displayed increased weight gain and developed large, steatotic livers. Quercetin glycosides were detected in the lingonberry and the blackcurrant diets. Conclusion. Lingonberries were shown to fully or partially prevent the detrimental metabolic effects induced by high-fat diet. Blackcurrants and bilberries had similar properties, but to a lower degree. We propose that the beneficial metabolic effects of lingonberries could be useful in preventing obesity and related disorders.
ISSN:2090-0724
2090-0732
DOI:10.1155/2014/403041