Catalyst-Free Visible-Light-Promoted Cyclization of Aldehydes: Access to 2,5-Disubstituted 1,3,4-Oxadiazole Derivatives

An efficient synthesis of a variety of 2,5-disubstituted 1,3,4-oxadiazole derivatives via a cyclization reaction by photoredox catalysis between aldehydes and hypervalent iodine­(III) reagents is described. The reaction proceeds under mild conditions and affords various target compounds in excellent...

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Bibliographic Details
Published in:ACS omega 2021-10, Vol.6 (40), p.26699-26706
Main Authors: Li, Jian, Wen, Jin-Xia, Lu, Xue-Chen, Hou, Guo-Quan, Gao, Xu, Li, Yang, Liu, Li
Format: Article
Language:English
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Summary:An efficient synthesis of a variety of 2,5-disubstituted 1,3,4-oxadiazole derivatives via a cyclization reaction by photoredox catalysis between aldehydes and hypervalent iodine­(III) reagents is described. The reaction proceeds under mild conditions and affords various target compounds in excellent yields. The commercially available aldehydes without preactivation and a simple visible-light-promoted procedure without any catalysts make this strategy an alternative to the conventional methods.
ISSN:2470-1343
2470-1343
DOI:10.1021/acsomega.1c04098