Lessons from a comparison of immuno-chromatographic and chemiluminescent micro-particle immunoassay in the diagnosis of syphilis

To synthesize lessons from comparison of results obtained from the immuno-chromatographic SD Bioline testing method and the chemiluminescent micro-particle immunoassay Architect in the diagnosis of syphilis at Livingstone Central hospital laboratory. The specificity and sensitivity of SD Bioline syp...

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Bibliographic Details
Published in:BMC research notes 2018-10, Vol.11 (1), p.701-701, Article 701
Main Authors: Masenga, Sepiso K, Mweemba, Mercy, Kachele, Annie, Chalubemba, Yahns, Toloka, Paul, Hamooya, Benson M
Format: Article
Language:English
Subjects:
Antibodies, Bacterial - blood
Architect syphilis
Architects
Bacterial infections
Bias
Chromatography
Chromatography - standards
Comparative analysis
Diagnosis
Disease control
Disease prevention
Humans
Immunoassay
Immunoassay - standards
Immunoglobulins
Infections
Information systems
Luminescent Measurements - standards
Medical laboratories
Research Note
Sample size
SD Bioline
Sensitivity and Specificity
Studies
Syphilis
Syphilis - blood
Syphilis - diagnosis
Syphilis Serodiagnosis - methods
Syphilis Serodiagnosis - standards
Treponema pallidum
Treponema pallidum - immunology
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Summary:To synthesize lessons from comparison of results obtained from the immuno-chromatographic SD Bioline testing method and the chemiluminescent micro-particle immunoassay Architect in the diagnosis of syphilis at Livingstone Central hospital laboratory. The specificity and sensitivity of SD Bioline syphilis 3.0 against the chemiluminescent immunoassay using the Architect syphilis Treponema pallidum (TP) was 85.3% and 91.3% respectively with substantial agreement between the two test methods (88%, ĸ  = 0.76; p 
ISSN:1756-0500
1756-0500
DOI:10.1186/s13104-018-3808-5