Generation of male germ cells in vitro from the stem cells

Infertility has become a serious disease since it affects 10%-15% of couples worldwide, and male infertility contributes to about 50% of the cases. Notably, a significant decrease occurs in the newborn population by 7.82 million in 2020 compared to 2016 in China. As such, it is essential to explore...

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Bibliographic Details
Published in:Asian journal of andrology 2023-01, Vol.25 (1), p.13-20
Main Authors: Cui, Ying-Hong, Chen, Wei, Wu, Si, Wan, Cai-Lin, He, Zuping
Format: Article
Language:English
Subjects:
application
in vitro generation
male germ cells
stem cells
Cell Differentiation
Embryonic Stem Cells
Germ Cells
Humans
Induced Pluripotent Stem Cells
Infant, Newborn
Infertility
Infertility, Male
Invited Review
Male
Stem cells
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Summary:Infertility has become a serious disease since it affects 10%-15% of couples worldwide, and male infertility contributes to about 50% of the cases. Notably, a significant decrease occurs in the newborn population by 7.82 million in 2020 compared to 2016 in China. As such, it is essential to explore the effective methods of obtaining functional male gametes for restoring male fertility. Stem cells, including embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), spermatogonial stem cells (SSCs), and mesenchymal stem cells (MSCs), possess the abilities of both self-renewal and differentiation into germ cells. Significantly, much progress has recently been achieved in the generation of male germ cells in vitro from various kinds of stem cells under the specified conditions, e.g., the coculturing with Sertoli cells, three-dimensional culture system, the addition of growth factors and cytokines, and/or the overexpression of germ cell-related genes. In this review, we address the current advance in the derivation of male germ cells in vitro from stem cells based on the studies of the peers and us, and we highlight the perspectives and potential application of stem cell-derived male gametes in reproductive medicine.
ISSN:1008-682X
1745-7262
1745-7262
1008-682X
DOI:10.4103/aja20226